B.L. Pool

TL;DR: The results indicate that AAI or AAII and their aristolactams exert their effect via a common reactive intermediate, probably the corresponding hydroxylamine, and suggest that the acids are preferentially metabolized by two totally different pathways in vitro, namely an oxidative pathways for AAI and a reductive pathway for AAII.

TL;DR: N-Nitrosodiethanolamine, a potent carcinogen, has not so far been found to be mutagenic in a wide range of test systems, but when incubated with alcohol dehydrogenase (ADH) in the presence of NAD, NDELA is converted to a potent mutagen.

TL;DR: DEHP was investigated in two long-term bioassays with Syrian golden hamsters using both i.p. (max. total dose 54 g/kg) and inhalative application and the occurrence of liver malignancies was significantly reduced after the combination treatment in the inhalation study.

TL;DR: The aim of this study was to investigate whether the newly synthesized bisphosphonic acidlinked N-Lost derivative BAD retains bone-seeking and cytostatic properties and to describe experiments on mutagenicity in vitro and on toxicity in vivo.

TL;DR: The sensitive detection of all carcinogenic nitrosamines was achieved, although a pattern of cell‐specific activation was not observable, and the new modification of the in vivo approach allowed thesensitive detection of NDMA genotoxicity in hepatic and in extrahepatic tissues.