H
Herbert Spring
Researcher at German Cancer Research Center
Publications - 75
Citations - 4538
Herbert Spring is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Nucleolus & Lampbrush chromosome. The author has an hindex of 34, co-authored 75 publications receiving 4442 citations.
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Journal Article
Drug Resistance and ATP-Dependent Conjugate Transport Mediated by the Apical Multidrug Resistance Protein, MRP2, Permanently Expressed in Human and Canine Cells
TL;DR: The cloned MRP2 (symbol ABCC2), a MRP family member localized to the apical membrane of polarized cells, demonstrates that MRP 2 confers resistance to cytotoxic drugs.
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cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats.
Markus W. Büchler,Jörg König,Manuela Brom,Jürgen Kartenbeck,Herbert Spring,Toru Horie,Dietrich Keppler +6 more
TL;DR: The results identify cMrp as a canalicular transport protein with a novel sequence and with a function similar to the one of the MRP.
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Expression of the MRP2 Gene-Encoded Conjugate Export Pump in Human Kidney Proximal Tubules and in Renal Cell Carcinoma
Thomas P. Schaub,Jürgen Kartenbeck,Jörg König,Herbert Spring,J. Dörsam,Gerd Staehler,Stephan Störkel,Walter F. Thon,Dietrich Keppler +8 more
TL;DR: MRP2, the first cloned ATP-dependent export pump for anionic conjugates detected in human kidney, may be involved in renal excretion of various anionic endogenous substances, xenobiotics, and cytotoxic drugs.
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Chemokines direct endothelial progenitors into tumor neovessels
TL;DR: It is shown that tumor vessels promote their own growth and development in a self-amplifying fashion, whereby neovessels of late-stage tumors release a battery of CC chemokines, which direct CCR2 and CCR5(+) progenitors into the vasculature.
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Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis
Hideyuki Kojima,Anne T. Nies,Jörg König,Wolfgang Hagmann,Herbert Spring,Masahito Uemura,Hiroshi Fukui,Dietrich Keppler +7 more
TL;DR: Down-regulation of uptake transporters may contribute to the impaired hepatobiliary elimination in advanced PBC, and partially altered localization of MRP2 may reflect the onset of changes leading to icteric PBC.