B
B. Leonard Holman
Researcher at Brigham and Women's Hospital
Publications - 96
Citations - 3074
B. Leonard Holman is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Ejection fraction & Myocardial infarction. The author has an hindex of 28, co-authored 96 publications receiving 3037 citations. Previous affiliations of B. Leonard Holman include Boston University & Harvard University.
Papers
More filters
Journal ArticleDOI
Right ventricular ejection fraction: An indicator of increased mortality in patients with congestive heart failure associated with coronary artery disease
TL;DR: It appears that the multiple factors contributing to the reduction in right ventricular ejection fraction make it a useful index not only for assessing biventricular function, but also for predicting patient outcome.
Journal ArticleDOI
Decreased Lymphocyte Beta-Adrenergic-Receptor Density in Patients with Heart Failure and Tolerance to the Beta-Adrenergic Agonist Pirbuterol
Wilson S. Colucci,R. Wayne Alexander,Gordon H. Williams,Robert E. Rude,B. Leonard Holman,Marvin A. Konstam,Joshua Wynne,Gilbert H. Mudge,Eugene Braunwald +8 more
TL;DR: It is concluded that tolerance to the hemodynamic and clinical effects of pirbuterol develops during long-term administration; this tolerance may be related to a decrease in myocardial or vascular beta-adrenergic receptors or both.
Journal Article
Uptake of the Cation Hexakis(2-methoxyisobutylisonitrile)-Technetium-99m by Human Carcinoma Cell Lines in Vitro
Laurence I. Delmon-Moingeon,David Piwnica-Worms,Annick D. Van den Abbeele,B. Leonard Holman,Alan Davison,Alun G. Jones +5 more
TL;DR: It is proposed that the plasma and mitochondrial membrane potentials play a major role in the uptake of the cationic compound hexakis(2-methoxyisobutylisonitrile)-technetium-99m, which exhibits interesting tumor cell interaction characteristics with promise for in vivo tumor imaging.
Journal ArticleDOI
Long-term therapy of heart failure with prazosin: A randomized double blind trial☆
TL;DR: There is evidence that repeated administration of prazosin to patients with severe congestive heart failure results in tolerance to its initial salutary effects as a vasodilator.
Journal ArticleDOI
Ejection fraction image: A noninvasive index of regional left ventricular wall motion
Denis E. Maddox,B. Leonard Holman,Joshua Wynne,John Idoine,J. Anthony Parker,Roger Uren,Jane M. Neill,Peter F. Cohn +7 more
TL;DR: The results suggest that the ejection fraction image is a sensitive indicator of regional left ventricular wall motion, as compared with angiographic analyses.