Infectious diseases can cause rapid population declines or species extinctions. Many pathogens of terrestrial and marine taxa are sensitive to temperature, rainfall, and humidity, creating synergisms that could affect biodiversity. Climate warming can increase pathogen development and survival rates, disease transmission, and host susceptibility. Although most host-parasite systems are predicted to experience more frequent or severe disease impacts with warming, a subset of pathogens might decline

/pdf/climate-warming-and-disease-risks-for-terrestrial-and-marine-gttfcx5ulf.pdf

Climate Warming and Disease Risks for Terrestrial and Marine Biota

Here we determine the complete genomic sequence of the Gram negative, g-Proteobacterium Vibrio cholerae El Tor N16961 to be 4,033,460 base pairs (bp). The genome consists of two circular chromosomes of 2,961,146 bp and 1,072,314 bp that together encode 3,885 open reading frames. The vast majority of recognizable genes for essential cell functions (such as DNA replication, transcription, translation and cell-wall biosynthesis) and pathogenicity (for example, toxins, surface antigens and adhesins) are located on the large chromosome. In contrast, the small chromosome contains a larger fraction (59%) of hypothetical genes compared with the large chromosome (42%), and also contains many more genes that appear to have origins other than the g-Proteobacteria. The small chromosome also carries a gene capture system (the integron island) and host ‘addiction’ genes that are typically found on plasmids; thus, the small chromosome may have originally been a megaplasmid that was captured by an ancestral Vibrio species. The V. cholerae genomic sequence provides a starting point for understanding how a free-living, environmental organism emerged to become a significant human bacterial pathogen.

/pdf/dna-sequence-of-both-chromosomes-of-the-cholera-pathogen-3k2iugka26.pdf

DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae

A variety of ecological applications require data from broad spatial extents that cannot be collected using field-based methods. Remote sensing data and techniques address these needs, which include identifying and detailing the biophysical characteristics of species' habitats, predicting the distribution of species and spatial variability in species richness, and detecting natural and human-caused change at scales ranging from individual landscapes to the entire world. Such measurements are subject to substantial errors that can be difficult to overcome, but corrected data are readily available and can be of sufficiently high resolution to be integrated into traditional field-based studies. Ecologists and conservation biologists are finding new ways to approach their research with the powerful suite of tools and data from remote sensing.

http://aix1.uottawa.ca/~jkerr/Kerr%20&%20Ostrovsky%202003%20TREE.pdf

From space to species: ecological applications for remote sensing

Preface.Acknowledgments.1 Introduction.1.1 Why Spatial Data in Public Health?1.2 Why Statistical Methods for Spatial Data?1.3 Intersection of Three Fields of Study.1.4 Organization of the Book.2 Analyzing Public Health Data.2.1 Observational vs. Experimental Data.2.2 Risk and Rates.2.2.1 Incidence and Prevalence.2.2.2 Risk.2.2.3 Estimating Risk: Rates and Proportions.2.2.4 Relative and Attributable Risks.2.3 Making Rates Comparable: Standardized Rates.2.3.1 Direct Standardization.2.3.2 Indirect Standardization.2.3.3 Direct or Indirect?2.3.4 Standardizing to What Standard?2.3.5 Cautions with Standardized Rates.2.4 Basic Epidemiological Study Designs.2.4.1 Prospective Cohort Studies.2.4.2 Retrospective Case-Control Studies.2.4.3 Other Types of Epidemiological Studies.2.5 Basic Analytic Tool: The Odds Ratio.2.6 Modeling Counts and Rates.2.6.1 Generalized Linear Models.2.6.2 Logistic Regression.2.6.3 Poisson Regression.2.7 Challenges in the Analysis of Observational Data.2.7.1 Bias.2.7.2 Confounding.2.7.3 Effect Modification.2.7.4 Ecological Inference and the Ecological Fallacy.2.8 Additional Topics and Further Reading.2.9 Exercises.3 Spatial Data.3.1 Components of Spatial Data.3.2 An Odyssey into Geodesy.3.2.1 Measuring Location: Geographical Coordinates.3.2.2 Flattening the Globe: Map Projections and Coordinate Systems.3.2.3 Mathematics of Location: Vector and Polygon Geometry.3.3 Sources of Spatial Data.3.3.1 Health Data.3.3.2 Census-Related Data.3.3.3 Geocoding.3.3.4 Digital Cartographic Data.3.3.5 Environmental and Natural Resource Data.3.3.6 Remotely Sensed Data.3.3.7 Digitizing.3.3.8 Collect Your Own!3.4 Geographic Information Systems.3.4.1 Vector and Raster GISs.3.4.2 Basic GIS Operations.3.4.3 Spatial Analysis within GIS.3.5 Problems with Spatial Data and GIS.3.5.1 Inaccurate and Incomplete Databases.3.5.2 Confidentiality.3.5.3 Use of ZIP Codes.3.5.4 Geocoding Issues.3.5.5 Location Uncertainty.4 Visualizing Spatial Data.4.1 Cartography: The Art and Science of Mapmaking.4.2 Types of Statistical Maps.MAP STUDY: Very Low Birth Weights in Georgia Health Care District 9.4.2.1 Maps for Point Features.4.2.2 Maps for Areal Features.4.3 Symbolization.4.3.1 Map Generalization.4.3.2 Visual Variables.4.3.3 Color.4.4 Mapping Smoothed Rates and Probabilities.4.4.1 Locally Weighted Averages.4.4.2 Nonparametric Regression.4.4.3 Empirical Bayes Smoothing.4.4.4 Probability Mapping.4.4.5 Practical Notes and Recommendations.CASE STUDY: Smoothing New York Leukemia Data.4.5 Modifiable Areal Unit Problem.4.6 Additional Topics and Further Reading.4.6.1 Visualization.4.6.2 Additional Types of Maps.4.6.3 Exploratory Spatial Data Analysis.4.6.4 Other Smoothing Approaches.4.6.5 Edge Effects.4.7 Exercises.5 Analysis of Spatial Point Patterns.5.1 Types of Patterns.5.2 Spatial Point Processes.5.2.1 Stationarity and Isotropy.5.2.2 Spatial Poisson Processes and CSR.5.2.3 Hypothesis Tests of CSR via Monte Carlo Methods.5.2.4 Heterogeneous Poisson Processes.5.2.5 Estimating Intensity Functions.DATA BREAK: Early Medieval Grave Sites.5.3 K Function.5.3.1 Estimating the K Function.5.3.2 Diagnostic Plots Based on the K Function.5.3.3 Monte Carlo Assessments of CSR Based on the K Function.DATA BREAK: Early Medieval Grave Sites.5.3.4 Roles of First- and Second-Order Properties.5.4 Other Spatial Point Processes.5.4.1 Poisson Cluster Processes.5.4.2 Contagion/Inhibition Processes.5.4.3 Cox Processes.5.4.4 Distinguishing Processes.5.5 Additional Topics and Further Reading.5.6 Exercises.6 Spatial Clusters of Health Events: Point Data for Cases and Controls.6.1 What Do We Have? Data Types and Related Issues.6.2 What Do We Want? Null and Alternative Hypotheses.6.3 Categorization of Methods.6.4 Comparing Point Process Summaries.6.4.1 Goals.6.4.2 Assumptions and Typical Output.6.4.3 Method: Ratio of Kernel Intensity Estimates.DATA BREAK: Early Medieval Grave Sites.6.4.4 Method: Difference between K Functions.DATA BREAK: Early Medieval Grave Sites.6.5 Scanning Local Rates.6.5.1 Goals.6.5.2 Assumptions and Typical Output.6.5.3 Method: Geographical Analysis Machine.6.5.4 Method: Overlapping Local Case Proportions.DATA BREAK: Early Medieval Grave Sites.6.5.5 Method: Spatial Scan Statistics.DATA BREAK: Early Medieval Grave Sites.6.6 Nearest-Neighbor Statistics.6.6.1 Goals.6.6.2 Assumptions and Typical Output.6.6.3 Method: q Nearest Neighbors of Cases.CASE STUDY: San Diego Asthma.6.7 Further Reading.6.8 Exercises.7 Spatial Clustering of Health Events: Regional Count Data.7.1 What Do We Have and What Do We Want?7.1.1 Data Structure.7.1.2 Null Hypotheses.7.1.3 Alternative Hypotheses.7.2 Categorization of Methods.7.3 Scanning Local Rates.7.3.1 Goals.7.3.2 Assumptions.7.3.3 Method: Overlapping Local Rates.DATA BREAK: New York Leukemia Data.7.3.4 Method: Turnbull et al.'s CEPP.7.3.5 Method: Besag and Newell Approach.7.3.6 Method: Spatial Scan Statistics.7.4 Global Indexes of Spatial Autocorrelation.7.4.1 Goals.7.4.2 Assumptions and Typical Output.7.4.3 Method: Moran's I .7.4.4 Method: Geary's c.7.5 Local Indicators of Spatial Association.7.5.1 Goals.7.5.2 Assumptions and Typical Output.7.5.3 Method: Local Moran's I.7.6 Goodness-of-Fit Statistics.7.6.1 Goals.7.6.2 Assumptions and Typical Output.7.6.3 Method: Pearson's chi2.7.6.4 Method: Tango's Index.7.6.5 Method: Focused Score Tests of Trend.7.7 Statistical Power and Related Considerations.7.7.1 Power Depends on the Alternative Hypothesis.7.7.2 Power Depends on the Data Structure.7.7.3 Theoretical Assessment of Power.7.7.4 Monte Carlo Assessment of Power.7.7.5 Benchmark Data and Conditional Power Assessments.7.8 Additional Topics and Further Reading.7.8.1 Related Research Regarding Indexes of Spatial Association.7.8.2 Additional Approaches for Detecting Clusters and/or Clustering.7.8.3 Space-Time Clustering and Disease Surveillance.7.9 Exercises.8 Spatial Exposure Data.8.1 Random Fields and Stationarity.8.2 Semivariograms.8.2.1 Relationship to Covariance Function and Correlogram.8.2.2 Parametric Isotropic Semivariogram Models.8.2.3 Estimating the Semivariogram.DATA BREAK: Smoky Mountain pH Data.8.2.4 Fitting Semivariogram Models.8.2.5 Anisotropic Semivariogram Modeling.8.3 Interpolation and Spatial Prediction.8.3.1 Inverse-Distance Interpolation.8.3.2 Kriging.CASE STUDY: Hazardous Waste Site Remediation.8.4 Additional Topics and Further Reading.8.4.1 Erratic Experimental Semivariograms.8.4.2 Sampling Distribution of the Classical Semivariogram Estimator.8.4.3 Nonparametric Semivariogram Models.8.4.4 Kriging Non-Gaussian Data.8.4.5 Geostatistical Simulation.8.4.6 Use of Non-Euclidean Distances in Geostatistics.8.4.7 Spatial Sampling and Network Design.8.5 Exercises.9 Linking Spatial Exposure Data to Health Events.9.1 Linear Regression Models for Independent Data.9.1.1 Estimation and Inference.9.1.2 Interpretation and Use with Spatial Data.DATA BREAK: Raccoon Rabies in Connecticut.9.2 Linear Regression Models for Spatially Autocorrelated Data.9.2.1 Estimation and Inference.9.2.2 Interpretation and Use with Spatial Data.9.2.3 Predicting New Observations: Universal Kriging.DATA BREAK: New York Leukemia Data.9.3 Spatial Autoregressive Models.9.3.1 Simultaneous Autoregressive Models.9.3.2 Conditional Autoregressive Models.9.3.3 Concluding Remarks on Conditional Autoregressions.9.3.4 Concluding Remarks on Spatial Autoregressions.9.4 Generalized Linear Models.9.4.1 Fixed Effects and the Marginal Specification.9.4.2 Mixed Models and Conditional Specification.9.4.3 Estimation in Spatial GLMs and GLMMs.DATA BREAK: Modeling Lip Cancer Morbidity in Scotland.9.4.4 Additional Considerations in Spatial GLMs.CASE STUDY: Very Low Birth Weights in Georgia Health Care District 9.9.5 Bayesian Models for Disease Mapping.9.5.1 Hierarchical Structure.9.5.2 Estimation and Inference.9.5.3 Interpretation and Use with Spatial Data.9.6 Parting Thoughts.9.7 Additional Topics and Further Reading.9.7.1 General References.9.7.2 Restricted Maximum Likelihood Estimation.9.7.3 Residual Analysis with Spatially Correlated Error Terms.9.7.4 Two-Parameter Autoregressive Models.9.7.5 Non-Gaussian Spatial Autoregressive Models.9.7.6 Classical/Bayesian GLMMs.9.7.7 Prediction with GLMs.9.7.8 Bayesian Hierarchical Models for Spatial Data.9.8 Exercises.References.Author Index.Subject Index.

/pdf/applied-spatial-statistics-for-public-health-data-5e3go3weys.pdf

Applied Spatial Statistics for Public Health Data

https://apha.confex.com/apha/responses/129am/165.pdf

Effects of environmental change on emerging parasitic diseases.

It has long been known that cholera outbreaks can be initiated when Vibrio cholerae, the bacterium that causes cholera, is present in drinking water in sufficient numbers to constitute an infective dose, if ingested by humans. Outbreaks associated with drinking or bathing in unpurified river or brackish water may directly or indirectly depend on such conditions as water temperature, nutrient concentration, and plankton production that may be favorable for growth and reproduction of the bacterium. Although these environmental parameters have routinely been measured by using water samples collected aboard research ships, the available data sets are sparse and infrequent. Furthermore, shipboard data acquisition is both expensive and time-consuming. Interpolation to regional scales can also be problematic. Although the bacterium, V. cholerae, cannot be sensed directly, remotely sensed data can be used to infer its presence. In the study reported here, satellite data were used to monitor the timing and spread of cholera. Public domain remote sensing data for the Bay of Bengal were compared directly with cholera case data collected in Bangladesh from 1992-1995. The remote sensing data included sea surface temperature and sea surface height. It was discovered that sea surface temperature shows an annual cycle similar to the cholera case data. Sea surface height may be an indicator of incursion of plankton-laden water inland, e.g., tidal rivers, because it was also found to be correlated with cholera outbreaks. The extensive studies accomplished during the past 25 years, confirming the hypothesis that V. cholerae is autochthonous to the aquatic environment and is a commensal of zooplankton, i.e., copepods, when combined with the findings of the satellite data analyses, provide strong evidence that cholera epidemics are climate-linked.

https://www.pnas.org/content/pnas/97/4/1438.full.pdf

Climate and infectious disease: use of remote sensing for detection of Vibrio cholerae by indirect measurement.

Since the launch of Landsat-1 28 years ago, remotely sensed data have been used to map features on the earth's surface. An increasing number of health studies have used remotely sensed data for monitoring, surveillance, or risk mapping, particularly of vector-borne diseases. Nearly all studies used data from Landsat, the French Systeme Pour l'Observation de la Terre, and the National Oceanic and Atmospheric Administration's Advanced Very High Resolution Radiometer. New sensor systems are in orbit, or soon to be launched, whose data may prove useful for characterizing and monitoring the spatial and temporal patterns of infectious diseases. Increased computing power and spatial modeling capabilities of geographic information systems could extend the use of remote sensing beyond the research community into operational disease surveillance and control. This article illustrates how remotely sensed data have been used in health applications and assesses earth-observing satellites that could detect and map environmental variables related to the distribution of vector-borne and other diseases.

/pdf/remote-sensing-and-human-health-new-sensors-and-new-41lslgpfl6.pdf

Remote sensing and human health: new sensors and new opportunities.

Remotely sensed characterizations of landscape composition were evaluated for Lyme disease exposure risk on 337 residential properties in two communities of suburban Westchester County, New York. Properties were categorized as no, low, or high risk based on seasonally adjusted densities of Ixodes scapularis nymphs, determined by drag sampling during June and July 1990. Spectral indices based on Landsat Thematic Mapper data provided relative measures of vegetation structure and moisture (wetness), as well as vegetation abundance (greenness). A geographic information system (GIS) was used to spatially quantify and relate the remotely sensed landscape variables to risk category. A comparison of the two communities showed that Chappaqua, which had more high-risk properties (P < 0.001), was significantly greener and wetter than Armonk (P < 0.001). Furthermore, within Chappaqua, high-risk properties were significantly greener and wetter than lower-risk properties in this community (P < 0.01). The high-risk properties appeared to contain a greater proportion of broadleaf trees, while lower-risk properties were interpreted as having a greater proportion of nonvegetative cover and/or open lawn. The ability to distinguish these fine scale differences among communities and individual properties illustrates the efficiency of a remote sensing/GIS-based approach for identifying peridomestic risk of Lyme disease over large geographic areas.

Landscape characterization of peridomestic risk for Lyme disease using satellite imagery.

A need exists to further develop new technologies, such as remote sensing and geographic information systems analysis, for estimating arthropod vector abundance in aquatic habitats and predicting adult vector population outbreaks. A brief overview of remote sensing technology in vector surveillance and control is presented, and suggestions are made on future research opportunities in light of current and proposed remote sensing systems.

Application of remote sensing to arthropod vector surveillance and control.

The cultivation of irrigated rice provides ideal larval habitat for a number of anopheline vectors of malaria throughout the world. Anopheles freeborni, a potential vector of human malaria, is associated with the nearly 240,000 hectares of irrigated rice grown annually in Northern and Central California; therefore, this species can serve as a model for the study of rice field anopheline population dynamics. Analysis of field data revealed that rice fields with early season canopy development, that are located near bloodmeal sources (i.e., pastures with livestock) were more likely to produce anopheline larvae than fields with less developed canopies located further from pastures. Remote sensing reflectance measurements of early-season canopy development and geographic information system (GIS) measurements of distanes between rice fields and pastures with livestock were combined to distinguish between high and low mosquito-producing rice fields. Using spectral and distance measures in either a discriminant or Bayesian analysis, the identification of high mosquito-producing fields was made with 85 percent accuracy nearly two months before anopheline larval populations peaked. Since omission errors were also minimized by these approaches, they could provide a new basis for directing abatement techniques for the control of malaria vectors.

B. Wood

Papers

Climate and infectious disease: use of remote sensing for detection of Vibrio cholerae by indirect measurement.

Remote sensing and human health: new sensors and new opportunities.

Landscape characterization of peridomestic risk for Lyme disease using satellite imagery.

Application of remote sensing to arthropod vector surveillance and control.

Estimating high mosquito-producing rice fields using spectral and spatial data