抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Bose-Einstein condensation (BEC) has been observed in a dilute gas of sodium atoms. A Bose-Einstein condensate consists of a macroscopic population of the ground state of the system, and is a coherent state of matter. In an ideal gas, this phase transition is purely quantum-statistical. The study of BEC in weakly interacting systems which can be controlled and observed with precision holds the promise of revealing new macroscopic quantum phenomena that can be understood from first principles.

Bose-Einstein condensation in a gas of sodium atoms

to be done in this area. Face recognition is a problem that scarcely clamoured for attention before the computer age but, having surfaced, has involved a wide range of techniques and has attracted the attention of some fine minds (David Mumford was a Fields Medallist in 1974). This singular application of mathematical modelling to a messy applied problem of obvious utility and importance but with no unique solution is a pretty one to share with students: perhaps, returning to the source of our opening quotation, we may invert Duncan's earlier observation, 'There is an art to find the mind's construction in the face!'.

Linear and nonlinear waves, by G. B. Whitham. Pp.636. £50. 1999. ISBN 0 471 35942 4 (Wiley).

Initial-value ordinary differential equation solution via variable order Adams method (SIVA/DIVA) package is collection of subroutines for solution of nonstiff ordinary differential equations. There are versions for single-precision and double-precision arithmetic. Requires fewer evaluations of derivatives than other variable-order Adams predictor/ corrector methods. Option for direct integration of second-order equations makes integration of trajectory problems significantly more efficient. Written in FORTRAN 77.

Solving Ordinary Differential Equations

Matter waves inside periodic potentials are well known from solid-state physics, where electrons interacting with a crystal lattice are considered. Atomic Bose-Einstein condensates inside light-induced periodic potentials (optical lattices) share many features with electrons in solids, but also with light waves in nonlinear materials and other nonlinear systems. Generally, atom-atom interactions in Bose-Einstein condensates lead to rich and interesting nonlinear effects. Furthermore, the experimental control over the parameters of the periodic potential and the condensate make it possible to enter regimes inaccessible in other systems. In this review, an introduction to the physics of ultracold bosonic atoms in optical lattices is given and an overview of the theoretical and experimental advances to date.

Dynamics of Bose-Einstein condensates in optical lattices

The existence of stable solitons in two- and three-dimensional (2D and 3D) media governed by the self-focusing cubic nonlinear Schrodinger equation with a periodic potential is demonstrated by means of the variational approximation (VA) and in direct simulations. The potential stabilizes the solitons against collapse. Direct physical realizations are a Bose-Einstein condensate (BEC) trapped in an optical lattice, and a light beam in a bulk Kerr medium of a photonic-crystal type. In the 2D case, the creation of the soliton in a weak lattice potential is possible if the norm of the field (number of atoms in BEC, or optical power in the Kerr medium) exceeds a threshold value (which is smaller than the critical norm leading to collapse). Both single-cell and multi-cell solitons are found, which occupy, respectively, one or several cells of the periodic potential, depending on the soliton's norm. Solitons of the former type and their stability are well predicted by VA. Stable 2D vortex solitons are found too.

https://iopscience.iop.org/article/10.1209/epl/i2003-00579-4/pdf

Multidimensional solitons in periodic potentials

The dynamics of localized excitations in array of Bose-Einstein condensates is investigated in the framework of the nonlinear lattice theory. The existence of temporarily stable ground states displaying an atomic population distributions localized on very few lattice sites (intrinsic localized modes), as well as, of atomic population distributions involving many lattice sites (envelope solitons), is studied both numerically and analytically. The origin and properties of these modes are shown to be inherently connected with the interplay between macroscopic quantum tunnelling and nonlinearity induced self-trapping of atoms in coupled BECs. The phenomenon of Bloch oscillations of these excitations is studied both for zero and non zero backgrounds. We find that in a definite range of parameters, homogeneous distributions can become modulationally unstable. We also show that bright solitons and excitations of shock wave type can exist in BEC arrays even in the case of positive scattering length. Finally, we argue that BEC array with negative scattering length in presence of linear potentials can display collapse.

Nonlinear excitations in arrays of Bose-Einstein condensates

Using the variational approximation and direct simulations in real and imaginary time, we find stable two-dimensional (2D) and 3D solitons in the self-attractive Gross-Pitaevskii equation (GPE) with a potential which is uniform in one direction $(z)$ and periodic in the others (however, the quasi-1D potentials cannot stabilize 3D solitons). The family of solitons includes single- and multiple-peaked ones. The results apply to Bose-Einstein condensates (BEC's) in optical lattices (OL's) and to spatial or spatiotemporal solitons in layered optical media. This is the first prediction of mobile 2D and 3D solitons in BEC's, as they keep mobility along $z$. Head-on collisions of in-phase solitons lead to their fusion into a collapsing pulse. Slow collisions between two multiple-peaked solitons whose main peaks are separated by an intermediate channel end up with their fusion into one single-peaked soliton in the middle channel, $\ensuremath{\simeq}1∕3$ of the original number of atoms being shed off. Stable localized states in the self-repulsive GPE with the low-dimensional OL combined with a parabolic trap are found too. Two such pulses in one channel perform recurrent elastic collisions, periodically featuring sharp interference patterns in the strong-overlap state.

Multidimensional solitons in a low-dimensional periodic potential

We show that the phenomenon of modulational instability in arrays of Bose–Einstein condensates confined to optical lattices gives rise to coherent spatial structures of localized excitations. These excitations represent thin discs in 1D, narrow tubes in 2D, and small hollows in 3D arrays, filled in with condensed atoms of much greater density compared to surrounding array sites. Aspects of the developed pattern depend on the initial distribution function of the condensate over the optical lattice, corresponding to particular points of the Brillouin zone. The long-time behaviour of the spatial structures emerging due to modulational instability is characterized by the periodic recurrence to the initial low-density state in a finite optical lattice. We propose a simple way to retain the localized spatial structures with high atomic concentration, which may be of interest for applications. A theoretical model, based on the multiple-scale expansion, describes the basic features of the phenomenon. Results of numerical simulations confirm the analytical predictions.

Regular spatial structures in arrays of Bose?Einstein condensates induced by modulational instability

We show that the phenomenon of modulational instability in arrays of Bose-Einstein condensates confined to optical lattices gives rise to coherent spatial structures of localized excitations. These excitations represent thin disks in 1D, narrow tubes in 2D, and small hollows in 3D arrays, filled in with condensed atoms of much greater density compared to surrounding array sites. Aspects of the developed pattern depend on the initial distribution function of the condensate over the optical lattice, corresponding to particular points of the Brillouin zone. The long-time behavior of the spatial structures emerging due to modulational instability is characterized by the periodic recurrence to the initial low-density state in a finite optical lattice. We propose a simple way to retain the localized spatial structures with high atomic concentration, which may be of interest for applications. Theoretical model, based on the multiple scale expansion, describes the basic features of the phenomenon. Results of numerical simulations confirm the analytical predictions.

https://arxiv.org/pdf/cond-mat/0306656.pdf

Bakhtiyor B. Baizakov

Papers

Multidimensional solitons in periodic potentials

Nonlinear excitations in arrays of Bose-Einstein condensates

Multidimensional solitons in a low-dimensional periodic potential

Regular spatial structures in arrays of Bose?Einstein condensates induced by modulational instability

Regular spatial structures in arrays of Bose-Einstein condensates induced by modulational instability