Showing papers by "Balbir Singh published in 1998"
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TL;DR: It is suggested that glucose turnover is 20% greater in malaria than in enteric fever, and this might reflect increased non-insulin-mediated glucose uptake in falciparum malaria and/or impaired gluconeogenesis inEnteric Fever, and may have implications for metabolic complications and their clinical management in both infections.
Abstract: To determine whether glucose turnover is increased in acute falciparum malaria compared to enteric fever in children, steady-state 6,6-D2-glucose turnover was measured in 9 Malaysian children with uncomplicated malaria (6 males and 3 females; median age 10 years, body weight 22 kg) and in 12 with uncomplicated enteric fever (8 males and 4 females; median age 10 years, body weight 24 kg) in acute illness, after quinine (5 malaria patients) and in convalescence. Baseline plasma glucose concentrations in malaria and enteric fever were similar (all values are medians [ranges in brackets]) 5·6 [3·2–11·3] vs. 5·5 [4·2–8·0] mmol/L), as were serum insulin levels (5·6 [0·4–26·5] vs. 6·8 [1·1–22·5] milliunits/L; P > 0·4). Glucose turnover in the malaria patients was higher than in patients with enteric fever (6·27 [2·71–6·87] vs. 5·20 [4·50–6·08] mg/kg.min; P = 0·02) and in convalescence (4·74 [3·35–6·79] mg/ kg.min; P = 0·05 vs. acute malaria study), and fell after quinine together with a rise in serum insulin (P = 0·03). Basal plasma lactate concentrations were higher in enteric fever than in malaria (3·4 [1· 8–6·4] vs. 0·8 [0·3–3·8] mmol/L; P < 0·0001) and correlated inversely with glucose turnover in this group (rs = −0·60; n = 12; P = 0·02).These data suggest that glucose turnover is 20% greater in malaria than in enteric fever. This might reflect increased non-insulin-mediated glucose uptake in falciparum malaria and/ or impaired gluconeogenesis in enteric fever, and may have implications for metabolic complications and their clinical management in both infections.
4 citations
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TL;DR: Dynamic assessment of parathyroid function in acute malaria and its role in morbidity and mortality in Western Australia.
Abstract: Objectives. To investigate the dynamic parathyroid
response to rapidly induced, sustained hypocalcaemia
in patients with acute malaria and in healthy
volunteers.
Design. Serum intact parathormone (PTH) concentrations
were measured on samples taken before and
during a variable-rate tri-sodium citrate infusion
designed to ‘clamp’ the whole blood ionised calcium
concentration 0.20 mmol L21 below baseline for 120
min.
Subjects. Six Malaysian patients aged 17–42 years
with acute malaria, four of whom were restudied in
convalescence, and 12 healthy controls aged 19–36
years.
Main outcome measures. Whole-blood ionised calcium
and serum intact PTH concentrations.
4 citations