Recent advances on the development of magnesium alloys for biodegradable implants.

Novel Magnesium Alloys Developed for Biomedical Application: A Review

Strategies to improve the corrosion resistance of microarc oxidation (MAO) coated magnesium alloys for degradable implants: Prospects and challenges

Review of magnesium-based biomaterials and their applications

To evaluate the ability of Mg-6Zn to replace titanium nails in the reconstruction of the intestinal tract in general surgery, we compared the Mg-6Zn and titanium implants with respect to their effects on rat's intestinal tract by biochemical, radiological, pathological and immunohistochemical methods. The results indicated that Mg-6Zn implants started to degrade at the third week and disintegrate at the fourth week. No bubbles appeared, which may be associated with intestinal absorption of the Mg-6Zn implants. Pathological analyses (containing liver, kidney and cecum tissues) and biochemical measurements, including serum magnesium, creatinine, blood urea nitrogen, glutamic-pyruvic-transaminase and glutamic-oxaloacetic-transaminase proved that degradation of Mg-6Zn did not harm the important organs, which is an improvement over titanium implants. Immunohistochemical results showed that Mg-6Zn could enhance the expression of transforming growth factor-β1. Mg-6Zn reduced the expression of tumor necrosis factor at different stages. In general, our study demonstrates that the Mg-6Zn alloy had good biocompatibility in vivo and performed better than titanium at promoting healing and reducing inflammation. It may be a promising candidate for stapler pins in intestinal reconstruction.

Comparison of the effects of Mg-6Zn and titanium on intestinal tract in vivo.

Preparation and characterization of a new biomedical Mg–Zn–Ca alloy

Mechanical properties, degradation performance and cytotoxicity of Mg–Zn–Ca biomedical alloys with different compositions

The effects of calcium on microstructure, texture and mechanical properties of hot-extruded Mg–Zn–Ca alloys were studied. The results showed that calcium elements can weaken the strong basal textures and refined the grain size of extruded Mg–Zn–Ca alloys. The weakening of extrusion textures with increasing content of Ca is related to the particle stimulated nucleation of recrystallization (PSN) and the particle retarded the growth of the dynamic recrystallization grains. The increase of the tensile elongation is attributing to the weakened extrusion textures and refined grains.

Effects of calcium on texture and mechanical properties of hot-extruded Mg–Zn–Ca alloys

Improving the corrosion resistance of Mg-4.0Zn-0.2Ca alloy by micro-arc oxidation.

In-vitro cytotoxicity and in-vivo biocompatibility of as-extruded Mg–4.0Zn–0.2Ca alloy

Baoping Zhang

Papers

Preparation and characterization of a new biomedical Mg–Zn–Ca alloy

Mechanical properties, degradation performance and cytotoxicity of Mg–Zn–Ca biomedical alloys with different compositions

Effects of calcium on texture and mechanical properties of hot-extruded Mg–Zn–Ca alloys

Improving the corrosion resistance of Mg-4.0Zn-0.2Ca alloy by micro-arc oxidation.

In-vitro cytotoxicity and in-vivo biocompatibility of as-extruded Mg–4.0Zn–0.2Ca alloy