B
Barbara A. Burleigh
Researcher at Harvard University
Publications - 69
Citations - 3552
Barbara A. Burleigh is an academic researcher from Harvard University. The author has contributed to research in topics: Trypanosoma cruzi & Intracellular parasite. The author has an hindex of 31, co-authored 63 publications receiving 3220 citations. Previous affiliations of Barbara A. Burleigh include Yale University & University of Western Ontario.
Papers
More filters
Journal ArticleDOI
The Mechanisms of Trypanosoma Cruzi Invasion of Mammalian Cells
TL;DR: Several lines of evidence suggest that parasite surface molecules mediate binding to host cells, whereas invasion of nonphagocytic cells involves recruitment of host-cell lysosomes, an unusual event apparently triggered by signal transduction.
Journal ArticleDOI
Oligopeptidase B-dependent signaling mediates host cell invasion by Trypanosoma cruzi
Elisabet V. Caler,Silvia G. Vaena de Avalos,Paul A. Haynes,Norma W. Andrews,Barbara A. Burleigh +4 more
TL;DR: It is shown that deletion of the gene encoding oligopeptidase B results in a marked defect in host cell invasion and in the establishment of infections in mice, and that this enzyme is responsible for the generation of a signaling agonist for mammalian cells.
Journal ArticleDOI
Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy
Sudeshna Fisch,Susan H. Gray,Stephane Heymans,Saptarsi M. Haldar,Baiqiu Wang,Otmar Pfister,Lei Cui,Ajay Kumar,Zhiyong Lin,Sucharita SenBanerjee,Hiranmoy Das,Christine A. Petersen,Ulrike Mende,Barbara A. Burleigh,Yan Zhu,Yigal M. Pinto,Ronglih Liao,Mukesh K. Jain +17 more
TL;DR: A combination of promoter analyses and gel-shift studies suggest that KLF15 can inhibit GATA4 and myocyte enhancer factor 2 function and is part of a heretofore unrecognized pathway regulating the cardiac response to hemodynamic stress.
Journal ArticleDOI
Cell signalling and Trypanosoma cruzi invasion
TL;DR: Differential engagement of host cell signalling pathways in a cell type‐specific manner and modulation ofHost cell gene expression by T. cruzi are becoming recognized as essential determinants of infectivity and intracellular survival by this pathogen.
Journal ArticleDOI
A Cytosolic Serine Endopeptidase from Trypanosoma cruzi Is Required for the Generation of Ca2+ Signaling in Mammalian Cells
TL;DR: The authors' data suggest that the T. cruzi oligopeptidase B participates in processing events in the cytoplasm of the parasites, generating a factor with Ca2+-signaling activity for mammalian cells.