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Barbara Burghardt
Researcher at Hoffmann-La Roche
Publications - 16
Citations - 636
Barbara Burghardt is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Xanthine oxidase & Superoxide. The author has an hindex of 14, co-authored 16 publications receiving 628 citations.
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Journal ArticleDOI
Antiperoxidant effects of dihydropyridine calcium antagonists.
TL;DR: On montre que ces antagonistes du Ca 2+ ont une large capacite antioxydante et peuvent proteger les phospholipides de the membrane du myocarde contre des agents peroxydants.
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Protection of cardiac membrane phospholipid against oxidative injury by calcium antagonists
TL;DR: The effects of the Ca2+ antagonist-antiperoxidants on the kinetics of cardiac membrane lipid peroxidation indicate that they inhibitperoxidation by intercepting oxy- and/or lipid free radical intermediates.
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Thiobarbituric Acid-reactive Malondialdehyde Formation During Superoxide-dependent, Iron-catalyzed Lipid Peroxidation: Influence of Peroxidation Conditions
TL;DR: It is demonstrated that the radical generator, at physiological pH and temperature, serves a dual role as both initiator of membrane phospholipid peroxidation and promotor of lipid peroxide breakdown and thiobarbituric acid-reactive malondialdehyde formation.
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Analysis of cardiac membrane phospholipid peroxidation kinetics as malondialdehyde: Nonspecificity of thiobarbituric acid-reactivity
TL;DR: As quantified spectrophotometrically, true MDA production during myocardial membrane peroxidation was identical in kinetics and in amount to the production of TBA-reactive substance from the peroxidized isolated membrane lipids, demonstrating that significant non-MDA species are generated during the per oxidation of cardiac membranes.
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Cardiac membrane vitamin E and malondialdehyde levels in heart muscle of normotensive and spontaneously-hypertensive rats.
TL;DR: Results offer direct evidence that SH-rat myocardium is vitamin E-deficient and highly peroxidative, relative to cardiac muscle of the normotensive W/K parent strain.