Barbara Huisamen

TL;DR: Investigation of the activation pattern of p38 MAPK during a multicycle preconditioning protocol, sustained ischaemia as well as reperfusion and to correlate these events with functional recovery of the isolated perfused rat heart suggests that attenuation of the kinase activity during sustainedIschaemia and reperfusions may be an essential element of the preconditionsing process.

TL;DR: It is concluded that treatment with PFK275-055 for 4 weeks protected the heart against ischaemia/reperfusion injury, elevated GLP-1 levels and improved metabolic control in obese, pre-diabetic rats.

TL;DR: The role of the melatonin receptors and events downstream of receptor activation, for example, the reperfusion injury salvage kinase (RISK), survivor activating factor enhancement and Notch pathways, the sirtuins, nuclear factor E2–related factor 2 (Nrf2) and translocases in the outer membrane (TOM70) will be discussed.

TL;DR: The results show that melatonin‐induced cardioprotection may be receptor dependent, and that its anti‐adrenergic actions, mediated by NOS and guanylyl cyclase activation, are important contributors.

TL;DR: Dysregulation of PKB is evident in the diabetic myocardium, PKB activation is not always directly correlated with glucose uptake and insulin resistance is associated with multiple alterations in signal transduction, both above and below P KB activation.