K
Kirsti Ytrehus
Researcher at University of Tromsø
Publications - 124
Citations - 5913
Kirsti Ytrehus is an academic researcher from University of Tromsø. The author has contributed to research in topics: Ischemic preconditioning & Ischemia. The author has an hindex of 34, co-authored 122 publications receiving 5462 citations. Previous affiliations of Kirsti Ytrehus include Health Science University & University of Bergen.
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Journal ArticleDOI
Glycogen synthase kinase-3β mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore
Magdalena Juhaszova,Dmitry B. Zorov,Dmitry B. Zorov,Suhn-Hee Kim,Suhn-Hee Kim,Salvatore Pepe,Salvatore Pepe,Qin Fu,Kenneth W. Fishbein,Bruce D. Ziman,Su Wang,Kirsti Ytrehus,Christopher L. Antos,Eric N. Olson,Steven J. Sollott +14 more
TL;DR: It is shown that reoxygenation after prolonged hypoxia reduces the reactive oxygen species (ROS) threshold for the mitochondrial permeability transition (MPT) in cardiomyocytes and that cell survival is steeply negatively correlated with the fraction of depolarized mitochondria.
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Preconditioning protects ischemic rabbit heart by protein kinase C activation.
TL;DR: Activation of protein kinase C with 4 beta-phorbol 12-myristate 13-acetate (PMA) or with 1-oleyl-2-acetyl glycerol (OAG) mimicked preconditioning in buffer-perfused hearts, which blocked protection from ischemic preconditionsing in isolated heart.
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Evidence that translocation of protein kinase C is a key event during ischemic preconditioning of rabbit myocardium.
TL;DR: Three interventions used to test critically the theory that ischemic preconditioning is the result of translocation of cytosolic protein kinase C (PKC) into the membranes where it can be activated support the translocation theory of isChemic precondsitioning.
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Exogenous hydrogen sulfide (H2S) protects against regional myocardial ischemia-reperfusion injury--Evidence for a role of K ATP channels.
TL;DR: These data provide the first evidence that exogenous H2S protects against irreversible ischemia–reperfusion injury in myocardium and support the involvement of KATP opening in the mechanism of action.
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Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart.
Derek J. Hausenloy,David Garcia-Dorado,Hans Erik Bøtker,Sean M. Davidson,James M. Downey,Felix B. Engel,Robert B. Jennings,Sandrine Lecour,Jonathan Leor,Rosalinda Madonna,Michel Ovize,Cinzia Perrino,Fabrice Prunier,Rainer Schulz,Joost P.G. Sluijter,Linda W. van Laake,Jakob Vinten-Johansen,Derek M. Yellon,Kirsti Ytrehus,Gerd Heusch,Péter Ferdinandy +20 more
TL;DR: The current state of ischaemic conditioning in both the experimental and clinical settings is critically analysed, recommendations for improving its translation into the clinical setting are provided, and novel therapeutic targets and new treatment strategies for reducing acute myocardial ischaemia/reperfusion injury are highlighted.