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Barbara Jaruga
Researcher at National Institutes of Health
Publications - 19
Citations - 2142
Barbara Jaruga is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Hepatitis & Signal transduction. The author has an hindex of 17, co-authored 19 publications receiving 2030 citations. Previous affiliations of Barbara Jaruga include Georgetown University Medical Center.
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Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners
TL;DR: It is suggested that natural killer cells kill activated hepatic stellate cells via retinoic acid early inducible 1/NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent mechanisms, thereby ameliorating liver fibrosis.
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Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS
Feng Hong,Barbara Jaruga,Won Ho Kim,Svetlana Radaeva,Osama N. El-Assal,Zhigang Tian,Van-Anh Nguyen,Bin Gao +7 more
TL;DR: It is suggested that STAT1 plays a harmful role in Con A-mediated hepatitis by activation of CD4(+) and NK T cells and directly inducing hepatocyte death, whereas STAT3 protects against liver injury by suppression of IFN-gamma signaling and induction of antiapoptotic protein Bcl-X(L).
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Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver: involvement of induction of Bcl-2 and Bcl-x(L) proteins.
Feng Hong,Won Ho Kim,Zhigang Tian,Zhigang Tian,Barbara Jaruga,Edward J. N. Ishac,Xuening Shen,Bin Gao +7 more
TL;DR: Elevation of serum interleukin-6 levels in ALD may overcome the inhibitory effect of ethanol on IL-6-mediated anti-apoptotic signals and prevent alcohol-induced hepatic apoptosis by induction of Bcl-2 and BCl-xL.
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IFN-γ/STAT1 acts as a proinflammatory signal in T cell-mediated hepatitis via induction of multiple chemokines and adhesion molecules: a critical role of IRF-1
TL;DR: It is demonstrated that IFN-γ/STAT1 plays an essential role in concanavalin A (ConA)-induced T cell hepatitis via activation of apoptotic signaling pathways.
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Crucial Role of IL-4/STAT6 in T Cell-Mediated Hepatitis: Up-Regulating Eotaxins and IL-5 and Recruiting Leukocytes
TL;DR: It is suggested that IL-4/STAT6 plays a critical role in Con A-induced hepatitis, via enhancing expression of eotaxins in hepatocytes and sinusoidal endothelial cells, and induces IL-5 expression, thereby facilitating recruitment of eosinophils and neutrophils into the liver and resulting in hepatitis.