B
Bärbel Rohrer
Researcher at Medical University of South Carolina
Publications - 97
Citations - 14566
Bärbel Rohrer is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Complement system & Alternative complement pathway. The author has an hindex of 32, co-authored 93 publications receiving 12761 citations. Previous affiliations of Bärbel Rohrer include Veterans Health Administration.
Papers
More filters
Journal ArticleDOI
Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye.
Marwa Belhaj,Balasubramaniam Annamalai,Nathaniel Parsons,Andrew Shuler,Jay D. Potts,Bärbel Rohrer,Bärbel Rohrer +6 more
TL;DR: ARPE-19 cells, a spontaneously arising human RPE cell line, has been used in long-term cell therapy experiments due to its lifetime functionality, and it is used here for encapsulation and delivery of the capsules to mouse eyes.
Journal ArticleDOI
Systemic Inflammation by Collagen-Induced Arthritis Affects the Progression of Age-Related Macular Degeneration Differently in Two Mouse Models of the Disease.
TL;DR: The data suggest systemic inflammation by CIA results in increased pathology in a dry AMD model, whereas it reduces lesions in a wetAMD model, which highlights the need for additional investigation into the role of secondary inflammation and sex-based differences on AMD.
Book ChapterDOI
Aseptic injury to epithelial cells alters cell surface complement regulation in a tissue specific fashion.
TL;DR: It is hypothesized that RPE cells respond to cellular stress as if it is infection, and reduce their surface expression of complement regulatory proteins to foster the local immune response.
Journal ArticleDOI
New Insights on Complement Inhibitor CD59 in Mouse Laser-Induced Choroidal Neovascularization: Mislocalization After Injury and Targeted Delivery for Protein Replacement
Gloriane Schnabolk,Mee Keong Beon,Stephen Tomlinson,Stephen Tomlinson,Bärbel Rohrer,Bärbel Rohrer +5 more
TL;DR: The role of CD59 in murine choroidal neovascularization (CNV), a model involving both CC and RPE, is investigated and whether CR2-CD59, a soluble targeted form of CD 59, provides protection is tested.
Journal Article
Explant cultures of Rpe65−/− mouse retina: a model to investigate cone opsin trafficking
TL;DR: Organ cultures may be a powerful low-throughput screening tool to identify novel compounds to promote cone survival and the critical role of agents that bind in the retinoid binding pocket is confirmed.