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Beatriz de las Heras
Researcher at Complutense University of Madrid
Publications - 37
Citations - 1741
Beatriz de las Heras is an academic researcher from Complutense University of Madrid. The author has contributed to research in topics: Chemistry & Apoptosis. The author has an hindex of 17, co-authored 33 publications receiving 1539 citations. Previous affiliations of Beatriz de las Heras include Carlos III Health Institute.
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Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation.
TL;DR: The pharmacological properties of the oil support the traditional use of N. sativa and its derived products as a treatment for rheumatism and related inflammatory diseases and is greater than is expected from its content of thymoquinone.
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Anti-Inflammatory and Immunomodulating Properties of a Sterol Fraction from Sideritis foetens CLEM
TL;DR: In vitro modulatory activity towards the classical pathway of the complement system shown by this fraction would correlate with the anti-inflammatory profile shown in vivo.
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Inhibition of the nuclear factor kappa B (NF-kappa B) pathway by tetracyclic kaurene diterpenes in macrophages. Specific effects on NF-kappa B-inducing kinase activity and on the coordinate activation of ERK and p38 MAPK.
Antonio Castrillo,Beatriz de las Heras,Sonsoles Hortelano,Benjamín Rodríguez,Angel Villar,Lisardo Boscá +5 more
TL;DR: Kaurenes impair the inflammatory signaling by inhibiting NIK, a member of the MAPK kinase superfamily that interacts with tumor necrosis factor receptor-associated factors, and mediate the activation of NF-kappaB by these receptors.
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Synthesis and induction of apoptosis signaling pathway of ent-kaurane derivatives.
Idaira Hueso-Falcón,Natalia Girón,Pilar de Paul Velasco,Juan Amaro-Luis,Angel G. Ravelo,Beatriz de las Heras,Sonsoles Hortelano,Ana Estévez-Braun +7 more
TL;DR: A role of kaurane derivatives as apoptotic inducers in tumor cells is provided via both the mitochondrial and membrane death receptor pathways, involving the Bcl-2 family proteins.
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Anti-inflammatory activity and phenolic profile of propolis from two locations in Región Metropolitana de Santiago, Chile.
Gabriela Valenzuela-Barra,Consuelo Castro,Catalina Figueroa,Andrés Barriga,Ximena Silva,Beatriz de las Heras,Sonsoles Hortelano,Carla Delporte +7 more
TL;DR: Both propolis showed in vivo topical anti-inflammatory activity against AA and TPA, the most active was Buin propolis and this difference is due in part to the variations in total phenols and flavonoids content and the phenolic profile.