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Ana Estévez-Braun
Researcher at University of La Laguna
Publications - 135
Citations - 2649
Ana Estévez-Braun is an academic researcher from University of La Laguna. The author has contributed to research in topics: Maytenus & Knoevenagel condensation. The author has an hindex of 25, co-authored 127 publications receiving 2323 citations. Previous affiliations of Ana Estévez-Braun include University of Las Palmas de Gran Canaria & Hospital Universitario de Canarias.
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Journal ArticleDOI
Recent Studies on Natural Products as Anticancer Agents
Angel G. Ravelo,Ana Estévez-Braun,Haydee Chavez-Orellana,Elisa Pérez-Sacau,Dulce Mesa-Siverio +4 more
TL;DR: This review deals with new natural molecules liable to become anticancer drugs, as well as recent specific strategies for a selective treatment of cancer.
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Antiplasmodial Activity of Naphthoquinones Related to Lapachol and β‐Lapachone
Elisa Pérez-Sacau,Ana Estévez-Braun,Angel G. Ravelo,David Gutiérrez Yapu,Alberto Giménez Turba +4 more
TL;DR: In this paper, the in vitro antiplasmodial activity of 26 naphthoquinone derivatives related to the natural lapachol and beta-lapachone was tested.
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Synthesis and pharmacophore modeling of naphthoquinone derivatives with cytotoxic activity in human promyelocytic leukemia HL-60 cell line.
Elisa Pérez-Sacau,Raquel G. Díaz-Peńate,Ana Estévez-Braun,Angel G. Ravelo,José Manuel García-Castellano,Leonardo Pardo,Mercedes Campillo +6 more
TL;DR: The computational models have facilitated the identification of structural elements of the ligands that are key for antitumoral properties and provide a valuable tool in designing new and more potent cytotoxic analogues.
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Inhibitory effects of lapachol derivatives on epstein-barr virus activation.
Elisa Pérez Sacau,Ana Estévez-Braun,Angel G. Ravelo,Esteban Ferro,Harunkuni Tokuda,Teruo Mukainaka,Hoyoku Nishino +6 more
TL;DR: Ten of the naphthoquinone lapachol derivatives tested for their inhibitory effects on Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate are reported for the first time, their structures being thoroughly determined by spectroscopic methods.
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Design and synthesis of a novel series of pyranonaphthoquinones as topoisomerase II catalytic inhibitors.
Sandra Jiménez-Alonso,Haydee Chavez Orellana,Ana Estévez-Braun,Angel G. Ravelo,Elisa Pérez-Sacau,Félix Machín +5 more
TL;DR: A new set of pyranonaphthoquinones derivatives is designed and synthesized and it is found that six of them act as catalytic inhibitors of the enzyme in vitro, which strongly preclude the enzyme from decatenating or relaxing suitable substrates.