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Beatriz M. Carreno
Researcher at Washington University in St. Louis
Publications - 59
Citations - 15718
Beatriz M. Carreno is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Immune system & Cytotoxic T cell. The author has an hindex of 33, co-authored 49 publications receiving 14099 citations. Previous affiliations of Beatriz M. Carreno include MedImmune.
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Journal Article
TAP associates with a unique class I conformation, whereas calnexin associates with multiple class I forms in mouse and man
Beatriz M. Carreno,Joyce C. Solheim,Michael R. Harris,Iwona T Stroynowski,Janet M. Connolly,Ted H. Hansen +5 more
TL;DR: Open forms of Ld are uniquely and specifically associated with TAP and that the conformational change in the class I H chain coincident with peptide binding induces TAP release, and a model for the sequential assembly of class I heterotrimers and their respective interactions with T AP and calnexin is proposed.
Journal ArticleDOI
BTLA: a new inhibitory receptor with a B7-like ligand.
Beatriz M. Carreno,Mary Collins +1 more
TL;DR: The B and T lymphocyte attenuator, BTLA, is a recently discovered Ig superfamily member as discussed by the authors, which has been proposed as the ligand for BTLA.
Journal ArticleDOI
Paradoxical inhibition of T-cell function in response to CTLA-4 blockade; heterogeneity within the human T-cell population.
David E. Anderson,Katarzyna D. Bieganowska,Amit Bar-Or,Enedina Maria Lobato de Oliveira,Beatriz M. Carreno,Mary Collins,David A. Hafler,David A. Hafler +7 more
TL;DR: It is demonstrated here that CTLA-4 blockade can enhance or inhibit the clonal expansion of different T cells that respond to the same antigen, depending on both the T-cell activation state and the strength of theT-cell receptor signal delivered during T- cell stimulation.
Journal ArticleDOI
Exogenous peptide ligand influences the expression and half‐life of free HLA class I heavy chains ubiquitously detected at the cell surface
Beatriz M. Carreno,Ted H. Hansen +1 more
TL;DR: Results indicate that surface HC10‐reactive molecules result largely from W6/32‐re active molecules following peptide and β2m dissociation, which are not only the precursors but also the end products in class I biosynthesis.
Journal Article
Binding of peptides lacking consensus anchor residue alters H-2Ld serologic recognition
Joyce C. Solheim,Beatriz M. Carreno,Joseph D. Smith,J Gorka,Nancy B. Myers,Zilong Wen,John M. Martinko,David R. Lee,Ted H. Hansen +8 more
TL;DR: Data imply that a mAb to a class I molecule can distinguish peptides with different motifs, possibly reflecting peptide-dependent conformational changes in the class I molecules.