Begoña Ruiz-Núñez

TL;DR: This review focuses on lifestyle changes, especially dietary habits, that are at the basis of chronic systemic low grade inflammation, insulin resistance and Western diseases, and the disturbance of the authors' inflammatory/anti-inflammatory balance is illustrated by dietary fatty acids and antioxidants.

TL;DR: Research regarding this heterogenic group of fatty acids and the mechanisms relating them to (chronic) systemic low-grade inflammation, insulin resistance, metabolic syndrome and notably CVD are summarized.

TL;DR: It is argued that the metabolic disease epidemic is largely based on a deficit in metabolic flexibility, and can be reversed by re-cultivating suppressed metabolic programs, which became obsolete in an affluent environment, particularly the ability to easily switch to ketone body and fat oxidation.

TL;DR: It is suggested that interaction with many other lifestyle factors determines whether SFA status has a relevant contributing effect in low-grade inflammation, lipoprotein changes and CAD risk, opposite to the reductionist approach of studying the effects of single nutrients.

TL;DR: Low circulating T3 and the apparent shift from T3 to rT3 may reflect more severely depressed tissue T3 levels, and the present findings might be in line with recent metabolomic studies pointing at a hypometabolic state.