B
Ben de Kruijff
Researcher at Utrecht University
Publications - 217
Citations - 16131
Ben de Kruijff is an academic researcher from Utrecht University. The author has contributed to research in topics: Membrane & Lipid bilayer. The author has an hindex of 69, co-authored 217 publications receiving 15329 citations. Previous affiliations of Ben de Kruijff include University of Hohenheim & Wageningen University and Research Centre.
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Journal ArticleDOI
Lipid II as a target for antibiotics
Eefjan Breukink,Ben de Kruijff +1 more
TL;DR: Progress in understanding of the antibacterial activities of these compounds are reviewed, which include lantibiotics, mannopeptimycins and ramoplanin, and factors that will be important in exploiting their potential as new treatments for bacterial infections are considered.
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The Nisin-Lipid II Complex Reveals a Pyrophosphate Cage that Provides a Blueprint for Novel Antibiotics
Shang-Te Danny Hsu,Eefjan Breukink,Eugene Tischenko,Mandy Lutters,Ben de Kruijff,Robert Kaptein,Alexandre M. J. J. Bonvin,Nico A. J. van Nuland +7 more
TL;DR: The structure shows a novel lipid II–binding motif in which the pyrophosphate moiety of lipid II is primarily coordinated by the N-terminal backbone amides of nisin via intermolecular hydrogen bonds, which provides a rationale for the conservation of the lanthionine rings among several lipid II-binding lantibiotics.
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An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II
Hester E. Hasper,Naomi E. Kramer,Naomi E. Kramer,James Leif Smith,Jeffrey D. Hillman,Cherian Zachariah,Oscar P. Kuipers,Ben de Kruijff,Eefjan Breukink +8 more
TL;DR: This work describes an alternative mechanism by which members of the lantibiotic family kill Gram-positive bacteria by removing lipid II from the cell division site (or septum) and thus block cell wall synthesis.
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Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane.
Maarten F. M. Engel,Lucie Khemtémourian,Cécile C. Kleijer,Hans Meeldijk,Jet Jacobs,Arie J. Verkleij,Ben de Kruijff,J. Antoinette Killian,Jo W.M. Höppener +8 more
TL;DR: A hypothesis that growth of hIAPP fibrils at the membrane causes membrane damage is proposed, which provides an additional mechanism next to the previously proposed role of oligomers as the main cytotoxic species of amyloidogenic proteins.
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Nonbilayer lipids affect peripheral and integral membrane proteins via changes in the lateral pressure profile.
TL;DR: The data suggest a general mechanism for the interaction between nonbilayer lipids and membrane proteins via the membrane lateral pressure, and predictions can be made for the effect of nonbilayers lipids on peripheral and integral membrane proteins.