R
Robert Kaptein
Researcher at Utrecht University
Publications - 437
Citations - 25223
Robert Kaptein is an academic researcher from Utrecht University. The author has contributed to research in topics: CIDNP & Nuclear magnetic resonance spectroscopy. The author has an hindex of 72, co-authored 436 publications receiving 24275 citations. Previous affiliations of Robert Kaptein include University of Groningen & University of Amsterdam.
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AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR
TL;DR: The AQUA and PROCHECK-NMR programs provide a means of validating the geometry and restraint violations of an ensemble of protein structures solved by solution NMR, and their outputs include a detailed breakdown of the restraint violations.
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Solution structure of the glucocorticoid receptor DNA-binding domain
Torleif Härd,Edwin Kellenbach,Rolf Boelens,Bonnie A. Maler,Karin Dahlman,Leonard P. Freedman,Leonard P. Freedman,Jan Carlstedt-Duke,Keith R. Yamamoto,Jan-Åke Gustafsson,Robert Kaptein +10 more
TL;DR: A model of the dimeric complex between the DBD and the glucocorticoid response element is proposed, consistent with previous results indicating that specific amino acid residues of the D BD are involved in protein-DNA and protein-protein interactions.
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Structure and Flexibility Adaptation in Nonspecific and Specific Protein-DNA Complexes
Charalampos G. Kalodimos,Nikolaos Biris,Alexandre M. J. J. Bonvin,Marc M. Levandoski,Marc Guennuegues,Rolf Boelens,Robert Kaptein +6 more
TL;DR: The solution structure and dynamics of the complex of a dimeric lac repressor DNA binding domain with nonspecific DNA is reported, showing that the protein-DNA interface of the nonspecial complex is flexible on biologically relevant time scales that may assist in the rapid and efficient finding of the target site.
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The Nisin-Lipid II Complex Reveals a Pyrophosphate Cage that Provides a Blueprint for Novel Antibiotics
Shang-Te Danny Hsu,Eefjan Breukink,Eugene Tischenko,Mandy Lutters,Ben de Kruijff,Robert Kaptein,Alexandre M. J. J. Bonvin,Nico A. J. van Nuland +7 more
TL;DR: The structure shows a novel lipid II–binding motif in which the pyrophosphate moiety of lipid II is primarily coordinated by the N-terminal backbone amides of nisin via intermolecular hydrogen bonds, which provides a rationale for the conservation of the lanthionine rings among several lipid II-binding lantibiotics.
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A protein structure from nuclear magnetic resonance data. Lac Repressor headpiece
TL;DR: This procedure combines model building with a restrained molecular dynamics algorithm, in which distance information from nuclear Overhauser effects is incorporated in the form of pseudo potentials, to determine the three-dimensional structure of biomolecules from nuclear magnetic resonance data.