Ben F. Rusy

TL;DR: The bulk of experimental evidence indicates that anesthetics do not produce their negative inotropic effect via an inhibitory action on mitochondrial electron transport, but the experimental act of removing myofibrils from their intracellular environment, or of removing the sarcolemma or making it hyperpermeable, appears to prevent some regulatory my ofibrillar phosphorylation reactions from taking place.

TL;DR: AV nodal conduction time increased as heart rate was increased, and this rate-dependency was enhanced by enflurane, which may in part explain the clinical impression that ventricular arrhythmias appear less likely to occur with en flurane than with halothane.

TL;DR: The data suggest that arrhythmias seen with halothane may be due in part to impaired conduction, as measured by both P–H and H–V intervals.

TL;DR: In a study of 120 patients with postoperative orthopedic pain, ibuprofen was more effective than acetaminophen-codeine and had a longer duration of action.

TL;DR: Regardless of the mechanism, hyperkalemia of this degree increased the ventricular slowing effect of both bupivacaine and lidocaine.