Bengt Larsson

TL;DR: Various drugs and other chemicals, such as organic amines, metals, polycyclic aromatic hydrocarbons, etc., are bound to melanin and retained in pigmented tissues for long periods and there are many indications of a connection between the melanin affinity of these agents and the induction of malignant melanoma.

TL;DR: The present study uses autoradiography and gamma spectrometry to show that intranasal instillation of manganese in rats results in initial uptake of the metal in the olfactory bulbs, and proposes that the neurotoxicity of inhaledManganese can circumvent the blood-brain barrier and gain direct access to the central nervous system.

TL;DR: It is suggested that melanin may be able to oxidize chlorpromazine to a positive ion radical, explaining the firm binding of the substance to melanin and the evidence in the literature favouring this possibility are discussed.

TL;DR: Antibodies were raised in rabbits against C- or N-terminal fragments of a cloned nitric oxide synthase (NOS) enzyme from rat cerebellum and used for demonstration of NOS-immunoreactive (Nos-IR) nerves in different tissues from the rat, which demonstrated the same neuronal elements, although with differences in intensity in the immunoreaction in some tissues.

TL;DR: Treatment with this selective CXCR2 antagonist did not reduce the frequency of severe exacerbations in patients with uncontrolled severe asthma, and this findings bring into question the role of CX CR2-mediated neutrophil recruitment in the pathobiology of exacerbation in severe refractory asthma.