Benjamin Eithan Reubinoff

TL;DR: The derivation of pluripotent embryonic stem (ES) cells from human blastocysts is described, providing a model to study early human embryology, an investigational tool for discovery of novel growth factors and medicines, and a potential source of cells for use in transplantation therapy.

TL;DR: The phenotype of the blastocyst-derived cell lines is very similar to that of monkey ES cells and pluripotent human embryonal carcinoma cells, but differs from that of mouse ES cells or the human germ-cell-derived stem cells as mentioned in this paper.

TL;DR: It is shown that endogenous signaling by bone morphogenetic protein-2 controls the differentiation of embryonic stem cells into this lineage, and that the conservation of developmental mechanisms at the cellular level can be exploited in this system to provide a facile route for the generation of neural precursors from pluripotent cells.

TL;DR: In this paper, a method for growing and propagating human embryonic stem cells towards the neural lineage has been proposed for the study of the cellular and molecular biology of human neural development, for the discovery of genes, growth factors, and differentiation factors that play a role in neural differentiation and regeneration, for drug discovery and for the development of screening assays for teratogenic, toxic and neuroprotective effects.

TL;DR: Biochemical analysis of the secreted form of this molecule shows that the monomeric form, whilst containing keratan sulphate, resembles mucins in its structure and its modification with O‐linked carbohydrate.