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Benjamin Leep
Publications - 1
Benjamin Leep is an academic researcher. The author has contributed to research in topics: Macrophage migration inhibitory factor & Internal medicine. The author has co-authored 1 publications.
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Inhibition of TKI-activated MIF/CXCR2 Pathway as a Novel Therapeutic Strategy in Acute Myeloid Leukemia
Christopher Hino,Verena Tadros,Benjamin Hiramoto,Benjamin Leep,Do Hyun Kim,Mark E. Reeves,David J. Baylink,Huynh Cao,Yi Xu +8 more
TL;DR: In this paper , the authors compared in vitro and ex vivo cytokine expression of gilteritinib (GILT)-treated and untreated AML cells and found that the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) is significantly expressed by GILT-treated blasts when compared to untreated controls, and further demonstrated that MIF expression promotes blast proliferation through the upregulation of its receptor CXCR2.