B
Benoit Jacques
Researcher at Université de Montréal
Publications - 2
Citations - 94
Benoit Jacques is an academic researcher from Université de Montréal. The author has contributed to research in topics: Binding site & Transmembrane domain. The author has an hindex of 2, co-authored 2 publications receiving 67 citations.
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Journal ArticleDOI
Structure–Function Profile of MmpL3, the Essential Mycolic Acid Transporter from Mycobacterium tuberculosis
Juan Manuel Belardinelli,Amira Yazidi,Liang Yang,Lucien Fabre,Lucien Fabre,Wei Li,Benoit Jacques,Shiva K. Angala,Isabelle Rouiller,Isabelle Rouiller,Helen I. Zgurskaya,Jurgen Sygusch,Mary Jackson +12 more
TL;DR: The combined genetic, biochemical, and biophysical studies indicate that MmpL3 and CmpL1 are structurally similar to Gram-negative resistance-nodulation and division efflux pumps and that multiresistance to these inhibitors is enabled by conformational changes in MMPL3.
Journal ArticleDOI
Active site remodeling during the catalytic cycle in metal-dependent fructose-1,6-bisphosphate aldolases.
TL;DR: Crystal structures of two bacterial metal (Zn2+)–dependent d-fructose-1,6-bisphosphate (FBP) aldolases in complex with substrate, analogues, and triose-P reaction products were determined to 1.5–2.0 Å resolution, enabling a novel mechanistic description of FBP C3–C4 bond cleavage.