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Bernard N. Fields
Researcher at Harvard University
Publications - 152
Citations - 9771
Bernard N. Fields is an academic researcher from Harvard University. The author has contributed to research in topics: Virus & Gene. The author has an hindex of 63, co-authored 152 publications receiving 9671 citations. Previous affiliations of Bernard N. Fields include Boston Children's Hospital & Albert Einstein College of Medicine.
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Journal ArticleDOI
Intestinal M cells: a pathway for entry of reovirus into the host
Jacqueline L. Wolf,Donald H. Rubin,Robert W. Finberg,Robert S. Kauffman,Arlene H. Sharpe,Jerry S. Trier,Bernard N. Fields +6 more
TL;DR: Findings suggest that M cells are the site where reovirus penetrates the intestinal epithelium.
Journal ArticleDOI
Sigma 1 protein of mammalian reoviruses extends from the surfaces of viral particles.
TL;DR: When sigma 1 protein was released from viral particles with mild heat and subsequently obtained in isolation, it was found to have a morphology identical to that of the fiber structures seen extending from the viral particles.
Journal ArticleDOI
Molecular basis of reovirus virulence: Role of the S1 gene
TL;DR: A genetic approach has been used to define the molecular basis for the different patterns of virulence and central nervous system cell tropism exhibited by reovirus types 1 and 3 and it is determined that the S1 genome segment is responsible for the differing cell Tropism of reov virus serotypes and is the major determinant of neurovirulence.
Journal ArticleDOI
Binding and transepithelial transport of immunoglobulins by intestinal M cells: demonstration using monoclonal IgA antibodies against enteric viral proteins.
R Weltzin,P Lucia-Jandris,Pierre Michetti,Bernard N. Fields,Jean-Pierre Kraehenbuhl,Marian R. Neutra +5 more
TL;DR: Results suggest that selective adherence of luminal antibody to M cells may facilitate delivery of virus-antibody complexes to mucosal lymphoid tissue, enhancing subsequent secretory immune responses or facilitating viral invasion.
Journal ArticleDOI
Antibody protects against lethal infection with the neurally spreading reovirus type 3 (Dearing).
TL;DR: Polyclonal and monoclonal antibodies protect mice from fatal infection with T3 after either footpad or intracerebral virus challenge and antibody mediated protection against this neurally spreading virus does not require neutralizing antibody or serum complement and occurs even in the face of established CNS infection.