B
Bertil Samuelsson
Researcher at Stockholm University
Publications - 201
Citations - 6228
Bertil Samuelsson is an academic researcher from Stockholm University. The author has contributed to research in topics: Protease & HIV-1 protease. The author has an hindex of 40, co-authored 201 publications receiving 6072 citations. Previous affiliations of Bertil Samuelsson include National Institute for Medical Research & Linköping University.
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Journal ArticleDOI
Novel reagent system for converting a hydroxy-group into an iodo-group in carbohydrates with inversion of configuration. Part 2
Per J. Garegg,Bertil Samuelsson +1 more
TL;DR: In this article, isolated primary and secondary hydroxy-groups in carbohydrate derivatives are transformed into iodo-groups with inversion of configuration on treatment with either triphenylphosphine, iodine, and imidazole or triphensyl-phosphines and 2,4,5-tri-iodoimidazoles at elevated temperatures.
Journal ArticleDOI
Regioselective reductive ring-opening of 4-methoxybenzylidene acetals of hexopyranosides. Access to a novel protecting-group strategy. Part 1
Rolf Johansson,Bertil Samuelsson +1 more
TL;DR: The 4-methoxybenzyl ether linkage in products containing benzyl ethers or other protective groups is selectively cleaved upon treatment with cerium(IV) ammonium nitrate in aqueous acetonitrile as discussed by the authors.
Journal ArticleDOI
Stimulation of renin release from rabbit renal cortex by arachidonic acid and prostaglandin endoperoxides.
P C Webber,C. Larsson,E. Anggard,Mats Hamberg,E. J. Corey,Kyriacos C. Nicolaou,Bertil Samuelsson +6 more
TL;DR: Results indicate that stimulation of renin release by C20:4 may depend more specifically on the action of PG endoperoxides than on the primary prostaglandins and raise the possibility of a direct action of the renal cortical PG system on renin secretion.
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In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor
Tse-I Lin,Oliver Lenz,Gregory Fanning,Thierry Verbinnen,Frederic Delouvroy,Annick Scholliers,Katrien Vermeiren,Åsa Rosenquist,Michael Edlund,Bertil Samuelsson,Lotta Vrang,Herman de Kock,Piet Wigerinck,Pierre Raboisson,Kenneth Simmen +14 more
TL;DR: TMC435350 is a highly specific and potent inhibitor of NS3/4A protease selected from a series of novel macrocyclic inhibitors that has the potential for combination with other anti-HCV agents and the favorable pharmacokinetic profile.
Journal ArticleDOI
Discovery and Development of Simeprevir (TMC435), a HCV NS3/4A Protease Inhibitor
Åsa Rosenquist,Bertil Samuelsson,Per-Ola Johansson,Maxwell D. Cummings,Oliver Lenz,Pierre Jean-Marie Bernard Raboisson,Kenny Simmen,Sandrine Vendeville,Herman de Kock,Magnus Nilsson,Andras Horvath,R. Kalmeijer,Guy De La Rosa,M. Beumont-Mauviel +13 more
TL;DR: The extensive medicinal chemistry effort to develop novel P2 cyclopentane macrocyclic inhibitors guided by HCV NS3 protease assays, the cellular replicon system, structure-based design, and a panel of DMPK assays are summarized.