Betsy C. Herold

TL;DR: It is demonstrated that the prevalence of community-acquired MRSA among children without identified risk factors is increasing, and the spectrum of disease associated with MRSA isolation is defined.

TL;DR: Using a series of intertypic recombinant mutant viruses, it is found that susceptibility to O-desulfated heparins can be transferred to HSV-1 by the gene for glycoprotein C ofHSV-2 (gC-2), which supports the notion that the envelope glycoproteins of HSv-1 and HSV -2 interact with different affinities for different structural features of heparin.

TL;DR: Results suggest that, in contrast to HSV-1, gC-2 does not play the key role in viral binding, and speculate that serotype differences in the contribution of gC to viral binding may contribute to serotypes differences in cell tropism.

TL;DR: This work compared the effects of modified heparin compounds on the binding and subsequent plaque formation of wild-type and gC-negative strains of HSV-1 and, in select cases, the binding of gB-negative virus to cells to suggest that gC and gB interact with different structural features of HS.

TL;DR: Using primary human culture systems, sulfated carbohydrate compounds that resemble HS and competitively inhibit infection by these pathogens are identified and are candidates for intravaginal formulations for the prevention of sexually transmitted diseases.