B
Birandra K. Sinha
Researcher at National Institutes of Health
Publications - 125
Citations - 5878
Birandra K. Sinha is an academic researcher from National Institutes of Health. The author has contributed to research in topics: DNA damage & Radical. The author has an hindex of 40, co-authored 122 publications receiving 5677 citations. Previous affiliations of Birandra K. Sinha include McGill University & Botanical Survey of India.
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Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells.
Gerald Batist,A Tulpule,Birandra K. Sinha,Aspandiar G. Katki,Charles E. Myers,Kenneth H. Cowan +5 more
TL;DR: The overexpression of a similar anionic glutathione transferase in human breast cancer cells selected for multidrug resistance and in rat hyperplastic liver nodules, which develop resistance to various hepatotoxins, suggests a possible role for this drug-conjugating enzyme in the mechanism of resistance in both of these states.
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Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats
TL;DR: The finding of similar biochemical changes associated with the development of resistance to various xenobiotics in HNs and to many naturally occurring antineoplastic agents and at least one carcinogen in DoxR MCF7 cells suggests that the mechanisms of resistance in these two models may be similar.
Journal Article
Adriamycin-induced Free Radical Formation in the Perfused Rat Heart: Implications for Cardiotoxicity
TL;DR: It is demonstrated that Adriamycin stimulates the formation of .OH in the isolated rat heart and it is suggested that this mechanism may be significant in AdRIamycin-induced cardiotoxicity.
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Differential formation of hydroxyl radicals by adriamycin in sensitive and resistant MCF-7 human breast tumor cells: implications for the mechanism of action
TL;DR: The differential .OH formation in these two cell lines is not due to diminished activities of flavin-dependent activating enzymes nor decreased accumulation of the drug in the cells but appears to be related to enhanced activities of detoxifying enzymes, particularly, glutathione peroxidases in the resistant cells.
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Free radicals and anticancer drug resistance: oxygen free radicals in the mechanisms of drug cytotoxicity and resistance by certain tumors.
TL;DR: Evidence pointing toward the significance of free radicals formation in drug toxicity is summarized and the role of decreased free radical formation and enhanced free radical scavenging and detoxification in the development of anticancer drug resistance by a spectrum of tumor cell types is evaluated.