Birgit A. Helm

TL;DR: The study indicates that non‐immunological degranulation by prototypic allergens, such as bee venom phos‐pholipase A2 or proteases associated with house dust mite emanations, is critically dependent on enzymatic activity and has potentially important implications for vaccine design in allergic and parasitic disease.

TL;DR: It is found that mast cells might be a source of IL-4 at the onset of specific immunity against sources of allergens such as bee venom that contain PLA2 and support the concept that the biologic action of an Ag on cells of the innate immune system can play a role in determining adaptive immune responses.

TL;DR: The recombinant peptide corresponding to residues 301-376 at the junction of constant regions 2 and 3 of the human IgE epsilon chain blocked the in vivo passive sensitization of human skin mast cells and in vitro sensitized human basophil granulocytes with human Ig E antibodies.

TL;DR: The solid-phase synthesis of a cyclic peptide containing the 21-residue epitope found in the A-B loop of the Cepsilon3 domain of human immunoglobulin E has been carried out.

TL;DR: In this paper, the capacity of N-and C-terminally truncated and chimeric human (h) IgE-derived peptides to inhibit the binding of I-labeled hIgE, and to engage cell lines expressing high and low affinity receptors (FcRI/II) was investigated.