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Birgit Vunk
Researcher at University of Tartu
Publications - 4
Citations - 45
Birgit Vunk is an academic researcher from University of Tartu. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 1, co-authored 2 publications receiving 16 citations.
Papers
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Journal ArticleDOI
Status update in the use of cell-penetrating peptides for the delivery of macromolecular therapeutics.
TL;DR: Most important clinical developments have occurred with the CPP-drug conjugate approaches that target various protein–protein interactions, and these have been highlighted subsequently.
Journal ArticleDOI
Predicting Transiently Expressed Protein Yields: Comparison of Transfection Methods in CHO and HEK293
Ly Porosk,Jekaterina Nebogatova,Heleri Heike Härk,Birgit Vunk,Piret Arukuusk,Urve Toots,Mart Ustav,Ülo Langel,Kaido Kurrikoff +8 more
TL;DR: A CPP-based transient protein expression approach that significantly outperformed the current industry standard workhorse method of PEI and lipoplex methods in both CHO and HEK293 producer cell lines is demonstrated.
Posted ContentDOI
Expressed therapeutic protein yields are predicted by transiently transfected mammalian cell population
Ly Porosk,Jekaterina Nebogatova,Heleri Heike Härk,Birgit Vunk,Piret Arukuusk,Urve Toots,Mart Ustav,Ülo Langel,Kaido Kurrikoff +8 more
TL;DR: This work shows that some of the most frequently used lab scale transfection efficacy assays fail to predict performance in the protein production settings, and validates reporter assays for assessing transfections methods in the lab that predict protein production in industrial settings.
Journal ArticleDOI
Tissue Analysis of Lung-Targeted Delivery of siRNA and Plasmid DNA.
TL;DR: In this article, a protocol is presented for analyzing a reporter signal from the lung tissue, which can be used in any lung-targeting drug delivery project, especially for nucleic acid delivery.