Björn Forsén

TL;DR: The WHO definition of the metabolic syndrome identifies subjects with increased cardiovascular morbidity and mortality and offers a tool for comparison of results from diferent studies.

TL;DR: GADab+ patients differ from both GADab- type 2 diabetic patients and type 1 diabetic patients with respect to beta-cell function, features of the metabolic syndrome, and type1 diabetes susceptibility genes, and it is proposed that LADA be defined as GADAB positivity (>5 relative units) in patients older than 35 years at onset of type 2 diabetes.

TL;DR: It is concluded that abdominal obesity, insulin resistance, and decreased resting metabolic rate are characteristic features of first-degree relatives of patients with NIDDM and that the decrease in resting metabolic rates is partially related to the degree of abdominal obesity.

TL;DR: A marked deterioration in beta-cell function precedes the onset of type 2 diabetes and these individuals can be identified early by knowledge of FPG, BMI, and family history of diabetes.

TL;DR: Individuals with a family history of type 2 diabetes are characterised by lower physical fitness, which cannot solely be explained byLower physical activity, and have an impaired capacity of beta cells to compensate for an increase in insulin resistance imposed by an increases in BMI.