Carola Saloranta

TL;DR: It is concluded that impaired glucose metabolism is common in the first-degree relatives of patients with NIDDM, despite their normal results on oral glucose-tolerance tests.

TL;DR: GADab+ patients differ from both GADab- type 2 diabetic patients and type 1 diabetic patients with respect to beta-cell function, features of the metabolic syndrome, and type1 diabetes susceptibility genes, and it is proposed that LADA be defined as GADAB positivity (>5 relative units) in patients older than 35 years at onset of type 2 diabetes.

TL;DR: A marked deterioration in beta-cell function precedes the onset of type 2 diabetes and these individuals can be identified early by knowledge of FPG, BMI, and family history of diabetes.

TL;DR: The hypothesis is advanced that in uncomplicated obesity, increased availability and oxidation of FFA leads, by the FFA/glucose cycle, to the impairment in glucose utilization, and in NIDDM, the defect in glucose usage is primary, and the enhanced rate of F FA oxidation may represent a compensatory phenomenon.

TL;DR: Prisposition for aggressive disease in young patients, often in a familial setting, suggests that earlier diagnosis of AIPmut pituitary adenomas may have clinical utility.