Blair R. Renshaw

TL;DR: The order, orientation, and intergenic distance of the nine IL-1 family genes that lie on human chromosome 2 are determined and the order and orientation of the mouse genes have been mapped, and the mouse locus compared with the human locus.

TL;DR: From the binding and signaling studies, it is concluded that the IL-18 receptor complex consists of IL- 18, theIL-1Rrp1, and another thus far unidentified receptor molecule.

TL;DR: In searching for a ligand for T1/ST2, this paper cloned a cell surface protein to which it binds, but this protein is unable to initiate signal transduction by the T1-ST2 receptor in several in vitro assays.

TL;DR: Two novel members of the interleukin-1 receptor (IL-1R) family, identified by homology searches of human genomic sequence data bases, are described, and a functional assay utilizing a panel of chimeric receptors containing the extracellular and transmembrane domains of either type I IL- 1R or IL-1r accessory protein (AcP) coupled to the cytoplasmic domains of all family members.

TL;DR: The presence of the same homozygous novel mutation in IL1RN in 2 unrelated Brazilian patients suggests that this genetic variant may be a founder mutation that has been introduced in the Brazilian population.