B
Bo Feng
Researcher at Pfizer
Publications - 55
Citations - 3258
Bo Feng is an academic researcher from Pfizer. The author has contributed to research in topics: Medicine & Organic anion transporter 1. The author has an hindex of 26, co-authored 47 publications receiving 2826 citations.
Papers
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Journal ArticleDOI
In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system.
Bo Feng,Jessica B. Mills,Ralph E. Davidson,Rouchelle J. Mireles,John S. Janiszewski,Matthew D. Troutman,Sonia M. de Morais +6 more
TL;DR: It is demonstrated that in vitro transporter assays help in understanding the role of P-glycoprotein-mediated efflux activity in determining the disposition of CNS drugs in vivo, and the transwell assay is a valuable in vitro assay to evaluate human P-gp interaction with compounds for assessing brain penetration of new chemical entities to treat CNS disorders.
Journal ArticleDOI
Development of a new permeability assay using low-efflux MDCKII cells
Li Di,Carrie Whitney-Pickett,John P. Umland,Hui Zhang,Xun Zhang,David F. Gebhard,Yurong Lai,James Federico,Ralph E. Davidson,Russ Smith,Eric L. Reyner,Caroline A. Lee,Bo Feng,Charles J. Rotter,Manthena V.S. Varma,Sarah Kempshall,Katherine S. Fenner,Ayman El-Kattan,Theodore E. Liston,Matthew D. Troutman +19 more
TL;DR: A new cell line, MDCKII-LE (low efflux), has been developed by selecting a subpopulation of low-efflux cells from MDCkII-WT using an iterative fluorescence-activated cell sorting technique with calcein-AM as a Pgp and efflux substrate.
Journal ArticleDOI
Demystifying brain penetration in central nervous system drug discovery. Miniperspective.
Li Di,Haojing Rong,Bo Feng +2 more
TL;DR: This Perspective provides important concepts about the blood-brain barrier (BBB) in drug discovery and how they should be applied effectively in designing successful CNS drugs.
Journal ArticleDOI
Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: the ITC evidence-based position.
J C Kalvass,Joseph W. Polli,DL Bourdet,Bo Feng,Huang Sm,X Liu,Quentin R. Smith,Lei Zhang,Maciej J. Zamek-Gliszczynski +8 more
TL;DR: Evidence from pharmacokinetic, pharmacodynamic, imaging, pharmacogenetic, and pharmacovigilance studies, along with drug safety reports, is presented supporting a low probability of modulating transporters at the human BBB by currently marketed drugs.
Journal ArticleDOI
Physicochemical determinants of human renal clearance.
Manthena V.S. Varma,Bo Feng,R. Scott Obach,Matthew D. Troutman,Jonathan Chupka,Howard Miller,Ayman El-Kattan +6 more
TL;DR: In conclusion, ionization state, lipophilicity, and polar descriptors are found to be the physicochemical determinants of renal clearance.