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Yurong Lai
Researcher at Bristol-Myers Squibb
Publications - 157
Citations - 6986
Yurong Lai is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Medicine & Drug. The author has an hindex of 47, co-authored 131 publications receiving 5942 citations. Previous affiliations of Yurong Lai include Sapporo Medical University & University of Washington.
Papers
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Journal ArticleDOI
Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug - Drug Interactions
Maria Karlgren,Anna Vildhede,Ulf Norinder,Ulf Norinder,Jacek R. Wisniewski,Emi Kimoto,Yurong Lai,Ulf Haglund,Per Artursson +8 more
TL;DR: The maximal transport activity (MTA) of each OATP in human liver was predicted from transport kinetics and protein quantification and the effects of a subset of inhibitors on atorvastatin uptake in vivo were predicted.
Journal ArticleDOI
Development of a new permeability assay using low-efflux MDCKII cells
Li Di,Carrie Whitney-Pickett,John P. Umland,Hui Zhang,Xun Zhang,David F. Gebhard,Yurong Lai,James Federico,Ralph E. Davidson,Russ Smith,Eric L. Reyner,Caroline A. Lee,Bo Feng,Charles J. Rotter,Manthena V.S. Varma,Sarah Kempshall,Katherine S. Fenner,Ayman El-Kattan,Theodore E. Liston,Matthew D. Troutman +19 more
TL;DR: A new cell line, MDCKII-LE (low efflux), has been developed by selecting a subpopulation of low-efflux cells from MDCkII-WT using an iterative fluorescence-activated cell sorting technique with calcein-AM as a Pgp and efflux substrate.
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Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data.
Hannah M. Jones,Hugh A. Barton,Yurong Lai,Yi An Bi,Emi Kimoto,Sarah Kempshall,Sonya C. Tate,Ayman El-Kattan,J. Brian Houston,Aleksandra Galetin,Katherine S. Fenner +10 more
TL;DR: This study illustrates the mechanistic and model-driven application of in vitro uptake and efflux data for human PK prediction for OATP substrates and shows the ability to capture the multiphasic plasma concentration-time profiles for such compounds using only preclinical data.
Journal ArticleDOI
In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development
Kim L. R. Brouwer,Dietrich Keppler,Keith Hoffmaster,Daniel A.J. Bow,Yaofeng Cheng,Yurong Lai,J E Palm,Bruno Stieger,Raymond Evers +8 more
TL;DR: In vitro tools to address key questions in drug development, including vesicle‐ and cell‐based systems, are discussed and how these methods can be used to assess the liability of compounds for transporter‐based drug–drug interactions in vivo is explored.
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Protein Abundance of Clinically Relevant Multidrug Transporters along the Entire Length of the Human Intestine
Marek Drozdzik,Christian Gröer,Jette Penski,Joanna Lapczuk,Marek Ostrowski,Yurong Lai,Bhagwat Prasad,Jashvant D. Unadkat,Werner Siegmund,Stefan Oswald +9 more
TL;DR: Analysis of intestinal transporters in healthy epithelium of the duodenum, the proximal and distal jejunum and ileum, and the ascending, transversal, descending, and sigmoidal colon of six organ donors provides further physiological pieces of the puzzle required to predict intestinal drug absorption in humans.