B
Brandy Scherer
Publications - 1
Citations - 3572
Brandy Scherer is an academic researcher. The author has contributed to research in topics: Sirtuin 1 & Saccharomyces cerevisiae. The author has an hindex of 1, co-authored 1 publications receiving 3392 citations.
Papers
More filters
Journal ArticleDOI
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Konrad T. Howitz,Kevin J. Bitterman,Haim Y. Cohen,Dudley W. Lamming,Siva Lavu,Jason G. Wood,Robert E. Zipkin,Phuong Chung,Anne Kisielewski,Li-Li Zhang,Brandy Scherer,David A. Sinclair +11 more
TL;DR: The potent activator resveratrol, a polyphenol found in red wine, lowers the Michaelis constant of SIRT1 for both the acetylated substrate and NAD+, and increases cell survival by stimulating Sirt1-dependent deacetylation of p53.