R
Robert E. Zipkin
Researcher at Harvard University
Publications - 9
Citations - 3828
Robert E. Zipkin is an academic researcher from Harvard University. The author has contributed to research in topics: Sirtuin & Sphingolipid. The author has an hindex of 5, co-authored 9 publications receiving 3648 citations.
Papers
More filters
Journal ArticleDOI
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Konrad T. Howitz,Kevin J. Bitterman,Haim Y. Cohen,Dudley W. Lamming,Siva Lavu,Jason G. Wood,Robert E. Zipkin,Phuong Chung,Anne Kisielewski,Li-Li Zhang,Brandy Scherer,David A. Sinclair +11 more
TL;DR: The potent activator resveratrol, a polyphenol found in red wine, lowers the Michaelis constant of SIRT1 for both the acetylated substrate and NAD+, and increases cell survival by stimulating Sirt1-dependent deacetylation of p53.
Patent
Compositions for manipulating the lifespan and stress response of cells and organisms
TL;DR: In this article, methods and compositions for modulating the activity of sirtuin deacetylase protein family members are presented, including p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms.
Patent
Sirtuin related therapeutics and diagnostics for neurodegenerative diseases
David A. Sinclair,Li-Huei Tsai,Minh Nguyen,Konrad T. Howitz,Robert E. Zipkin,Kevin J. Bitterman +5 more
TL;DR: In this paper, methods and compositions for modulating the activity of sirtuin deacetylase protein family members are presented, e.g., p53 activity, lifespan and sensitivity to stress of cells and organisms.
Patent
Compositions and methods for selectively activating human sirtuins
TL;DR: In this paper, a method for identifying selective activators of SIRT5 and/or SIRT1 and methods for using them in the modulation of the SIRT-5 and-SIRT-1 is presented.
Patent
SIRT1 modulators for manipulating cell/organism lifespan/stress response
TL;DR: In this paper, methods and compositions for modulating the activity of sirtuin deacetylase protein family members are presented, including p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms.