B
Brenda Costall
Researcher at University of Bradford
Publications - 323
Citations - 15163
Brenda Costall is an academic researcher from University of Bradford. The author has contributed to research in topics: Dopamine & Nucleus accumbens. The author has an hindex of 67, co-authored 323 publications receiving 14945 citations.
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Journal ArticleDOI
Exploration of mice in a black and white test box: Validation as a model of anxiety
Brenda Costall,B.J. Jones,M.E. Kelly,M.E. Kelly,R.J. Naylor,R.J. Naylor,D.M. Tomkins,D.M. Tomkins +7 more
TL;DR: It is concluded that the characteristic change in mouse exploratory behaviour caused by anxiolytic agents is to preferentially increase exploratorybehaviour in the white aversive section of the black and white test box.
Journal ArticleDOI
Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity.
John Hughes,P.R. Boden,Brenda Costall,A Domeney,E Kelly,David C. Horwell,John C. Hunter,R. D. Pinnock,Geoffrey N. Woodruff +8 more
TL;DR: Evidence is provided of a selective role for CCK-B receptors in the control of anxiety in mice previously made tolerant to diazepam and members of a class of anxiolytic agents that have a greatly improved profile compared with benzodiazepines or serotonin-related anxIOlytics.
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Effects of the 5-HT3 receptor antagonist, GR38032F, on raised dopaminergic activity in the mesolimbic system of the rat and marmoset brain.
TL;DR: It is concluded that the 5‐HT3 receptor antagonist GR38032F, and the neuroleptic agents fluphenazine, sulpiride and haloperidol, can reduce raised mesolimbic dopaminergic activity in the rat and marmoset.
Journal ArticleDOI
The potential anxiolytic activity of GR38032F, a 5-HT3-receptor antagonist.
B.J. Jones,Brenda Costall,A.M. Domeney,M.E. Kelly,Robert J. Naylor,Nigel R. Oakley,M.B. Tyers +6 more
TL;DR: It is concluded that GR38032F is potentially a very potent anxiolytic agent without sedative, anticonvulsant or hypnotic activity.
Journal ArticleDOI
Gestational stress induces post-partum depression-like behaviour and alters maternal care in rats
TL;DR: Data show that GS can alter maternal behaviour in mothers, and this might contribute to alterations in the offspring, and also hypersecreted ACTH and CORT in response to an acute stress challenge.