Institution
Parke-Davis
About: Parke-Davis is a based out in . It is known for research contribution in the topics: Receptor & Alkyl. The organization has 4140 authors who have published 4596 publications receiving 182248 citations. The organization is also known as: Parke, Davis & Company.
Topics: Receptor, Alkyl, Agonist, Atorvastatin, Population
Papers published on a yearly basis
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TL;DR: The results indicate that the activation of Raf is suppressed and that its inactivation is accelerated by a downstream component(s) of the MAP kinase pathway.
3,444 citations
TL;DR: Results indicate that the MAPK pathway is essential for growth and maintenance of the ras-transformed phenotype and PD 098059 is an invaluable tool that will help elucidate the role of theMAPK cascade in a variety of biological settings.
Abstract: Treatment of cells with a variety of growth factors triggers a phosphorylation cascade that leads to activation of mitogen-activated protein kinases (MAPKs, also called extracellular signal-regulated kinases, or ERKs). We have identified a synthetic inhibitor of the MAPK pathway. PD 098059 [2-(2'-amino-3'-methoxyphenyl)-oxanaphthalen-4-one] selectively inhibited the MAPK-activating enzyme, MAPK/ERK kinase (MEK), without significant inhibitory activity of MAPK itself. Inhibition of MEK by PD 098059 prevented activation of MAPK and subsequent phosphorylation of MAPK substrates both in vitro and in intact cells. Moreover, PD 098059 inhibited stimulation of cell growth and reversed the phenotype of ras-transformed BALB 3T3 mouse fibroblasts and rat kidney cells. These results indicate that the MAPK pathway is essential for growth and maintenance of the ras-transformed phenotype. Further, PD 098059 is an invaluable tool that will help elucidate the role of the MAPK cascade in a variety of biological settings.
2,697 citations
TL;DR: It is shown that cardiac hypertrophy is induced by the calcium-dependent phosphatase calcineurin, which dephosphorylates the transcription factor NF-AT3, enabling it to translocate to the nucleus.
2,596 citations
TL;DR: It is suggested that glial glutamate transporters provide the majority of functional glutamate transport and are essential for maintaining low extracellular glutamate and for preventing chronic glutamate neurotoxicity.
2,482 citations
TL;DR: The proapoptotic function of BAD is regulated by the PI 3-kinase-Akt pathway, and active, but not inactive, forms of Akt were found to phosphorylate BAD in vivo and in vitro at the same residues that are phosphorylated in response to IL-3.
Abstract: BAD is a distant member of the Bcl-2 family that promotes cell death. Phosphorylation of BAD prevents this. BAD phosphorylation induced by interleukin-3 (IL-3) was inhibited by specific inhibitors of phosphoinositide 3-kinase (PI 3-kinase). Akt, a survival-promoting serine-threonine protein kinase, was activated by IL-3 in a PI 3-kinase-dependent manner. Active, but not inactive, forms of Akt were found to phosphorylate BAD in vivo and in vitro at the same residues that are phosphorylated in response to IL-3. Thus, the proapoptotic function of BAD is regulated by the PI 3-kinase-Akt pathway.
2,321 citations
Authors
Showing all 4140 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Gabriel Núñez | 148 | 466 | 105724 |
| Charles Taylor | 126 | 741 | 77626 |
| Nicholas J. Schork | 125 | 587 | 62131 |
| Bertram Pitt | 107 | 754 | 78458 |
| Robert J. Coffey | 103 | 402 | 42409 |
| Richard J. Whitley | 103 | 516 | 44049 |
| Robert W. Schrier | 99 | 586 | 38996 |
| Alan R. Saltiel | 99 | 336 | 49325 |
| Emilio Ros | 95 | 554 | 37490 |
| Michael Aviram | 94 | 479 | 31141 |
| Joseph A. Loo | 89 | 413 | 26162 |
| Rainer Schulz | 87 | 482 | 27135 |
| Gordon L. Amidon | 86 | 466 | 35880 |
| Kevin K.W. Wang | 79 | 384 | 20510 |
| David Ginsburg | 76 | 266 | 19779 |