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Brian E. Applegate
Researcher at University of Southern California
Publications - 155
Citations - 3007
Brian E. Applegate is an academic researcher from University of Southern California. The author has contributed to research in topics: Optical coherence tomography & Cochlea. The author has an hindex of 28, co-authored 140 publications receiving 2621 citations. Previous affiliations of Brian E. Applegate include Texas A&M University & Case Western Reserve University.
Papers
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Patent
Method for optical coherence tomography imaging with molecular contrast
Joseph A. Izatt,Divakar K. Rao,Changhuei Yang,Michael A. Choma,Siavash Yazdanfar,Andrew M. Rollins,Brian E. Applegate +6 more
TL;DR: A plurality of optical coherence tomography (OCT) images may be acquired, at least some of which are acquired at different stimulus intensities as discussed by the authors, which are used to profile the molecular contrast agent concentration distribution of the sample.
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Noninvasive in vivo imaging reveals differences between tectorial membrane and basilar membrane traveling waves in the mouse cochlea
Hee Yoon Lee,Patrick D. Raphael,Jesung Park,Audrey K. Ellerbee,Brian E. Applegate,John S. Oghalai +5 more
TL;DR: Volumetric optical coherence tomography vibrometry is described, a new technique capable of depth-resolved displacement measurements in 3D space with picometer sensitivity within the unopened mouse cochlea, which finds that the tectorial membrane sustains traveling wave propagation differently than the more commonly measured basilar membrane.
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The formation of cyclic water complexes by sequential ring insertion: Experiment and theory
TL;DR: In this paper, a combined experimental and theoretical effort was made to explore the ring insertion process in detail, and the results provided important new insights into the dynamics of hydrogen-bonded networks.
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Two-Dimensional Cochlear Micromechanics Measured In Vivo Demonstrate Radial Tuning within the Mouse Organ of Corti
Hee Yoon Lee,Patrick D. Raphael,Anping Xia,Jinkyung Kim,Nicolas Grillet,Brian E. Applegate,Audrey K. Ellerbee Bowden,John S. Oghalai +7 more
TL;DR: The 2-D motion of the organ of Corti in mice was measured and it was found that the structures that stimulate the outer hair cell stereocilia, the tectorial membrane and reticular lamina, were sharply tuned in the radial direction, suggesting that radial tuning comes from passive mechanics within the hair cell epithelium, and that these mechanics, at least in part, may tune the gain of cochlear amplification.
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Real-time quadrature projection complex conjugate resolved Fourier domain optical coherence tomography.
TL;DR: A novel algorithm for full-range imaging by suppression of the complex conjugate artifact in phase-shifting Fourier domain optical coherence tomography using the projection of multiple phase- shifted interferograms onto an orthogonal basis set to reconstruct the complex interferogram.