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Brian E. Cathers
Researcher at University of Texas at Austin
Publications - 4
Citations - 841
Brian E. Cathers is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: G-quadruplex & Telomerase. The author has an hindex of 4, co-authored 4 publications receiving 781 citations.
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Journal ArticleDOI
Inhibition of human telomerase by a G-quadruplex-interactive compound.
Daekyu Sun,Brian D. Thompson,Brian E. Cathers,Miguel Salazar,Sean M. Kerwin,John O. Trent,Terence C. Jenkins,Stephen Neidle,Laurence H. Hurley +8 more
Journal ArticleDOI
Inhibition of human telomerase by 7-deaza-2'-deoxyguanosine nucleoside triphosphate analogs: potent inhibition by 6-thio-7-deaza-2'-deoxyguanosine 5'-triphosphate.
TL;DR: It is shown that TDG-TP, and to a lesser extent OMDG- TP, can serve as substrates for both templated (Klenow exo) and nontemplated (terminal transferase) DNA polymerases.
Journal ArticleDOI
pH Dependence of inhibitors targeting the occluding loop of cathepsin B.
TL;DR: The pH dependence of two prime-side-binding compounds is examined to suggest that targeting of the occluding loop of cathepsin B may be a poor inhibitor design strategy if the enzyme environment has a pH greater than 5.5.