M
Miguel Salazar
Researcher at University of Texas at Austin
Publications - 26
Citations - 2599
Miguel Salazar is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: DNA & Telomerase. The author has an hindex of 18, co-authored 25 publications receiving 2491 citations. Previous affiliations of Miguel Salazar include University of Washington.
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Journal ArticleDOI
Inhibition of human telomerase by a G-quadruplex-interactive compound.
Daekyu Sun,Brian D. Thompson,Brian E. Cathers,Miguel Salazar,Sean M. Kerwin,John O. Trent,Terence C. Jenkins,Stephen Neidle,Laurence H. Hurley +8 more
Journal ArticleDOI
NMR-Based Model of a Telomerase-Inhibiting Compound Bound to G-Quadruplex DNA†
Oleg Yu. Fedoroff,Miguel Salazar,Haiyong Han,Violetta V. Chemeris,Sean M. Kerwin,Laurence H. Hurley +5 more
TL;DR: 3,4,9, 10-perylenetetracarboxylic diimide-based ligands are identified as potent inhibitors of human telomerase by using a primer extension assay that does not use PCR-based amplification of the telomersase primer extension products.
Journal ArticleDOI
Structure of a DNA:RNA hybrid duplex. Why RNase H does not cleave pure RNA.
TL;DR: The solution structure of the DNA:RNA hybrid duplex d(GTCACATG):r(caugugac) has been determined by means of two-dimensional nuclear Overhauser effect (2D-NOE) spectra, restrained molecular dynamics and full-relaxation matrix stimulation of the 2D -NOE spectra as mentioned in this paper.
Journal ArticleDOI
A DNA polymerase stop assay for G-quadruplex-interactive compounds.
TL;DR: It is found that BSU-1051 leads to enhanced arrest of DNA synthesis in the presence of K+ by stabilizing an intramolecular G-quadruplex structure formed by four repeats of either TTGGGG or TTAGGG in the template strand.
Journal ArticleDOI
G-quadruplexes as targets for drug design.
Laurence H. Hurley,Richard T. Wheelhouse,Daekyu Sun,Sean M. Kerwin,Miguel Salazar,Oleg Yu. Fedoroff,Frank Xiaoguang Han,Haiyong Han,Elzbieta Izbicka,Daniel D. Von Hoff +9 more
TL;DR: This review describes the design of three separate groups of G- quadruplex-interactive compounds and their interaction with G-quadruplex DNA, and describes the experiments that relate the biological effects to their interactions with the quadruplex.