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Brian H. Harvey
Researcher at North-West University
Publications - 162
Citations - 5802
Brian H. Harvey is an academic researcher from North-West University. The author has contributed to research in topics: Antidepressant & Deer mouse. The author has an hindex of 43, co-authored 162 publications receiving 5126 citations. Previous affiliations of Brian H. Harvey include University of Cape Town & University of North Texas Health Science Center.
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Journal ArticleDOI
The nature of relapse in schizophrenia.
TL;DR: Given the difficulties in identifying those at risk of relapse, the ineffectiveness of rescue medications in preventing full-blown psychotic recurrence and the potentially serious consequences, adherence and other factors predisposing to relapse should be a major focus of attention in managing schizophrenia.
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Local, but not systemic, administration of serotonergic antidepressants decreases hippocampal nitric oxide synthase activity.
TL;DR: It is found that citalopram, paroxetine, imipramine and N(G)-nitro-L-arginine dose dependently decreased the hippocampal NOS activity in vitro, in vivo and ex vivo, and this may reflect a secondary action of antidepressants on the glutamate NMDA receptor following their primary inhibitory action at the 5-HT transporter.
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Stress–restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus
TL;DR: Stress–restress-mediated glucocorticoid release activates iNOS, followed by a reactive downregulation of hippocampal NMDA receptors and dysregulation of inhibitory GABA pathways, which has important implications in stress-related hippocampal degeneration.
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Social isolation rearing induces mitochondrial, immunological, neurochemical and behavioural deficits in rats, and is reversed by clozapine or N-acetyl cysteine.
Marissa Moller,Jan L. du Preez,Francois P. Viljoen,Michael Berk,Michael Berk,Robin Emsley,Brian H. Harvey +6 more
TL;DR: In conclusion, SIR induces mitochondrial and immune-inflammatory changes that underlie cortico-striatal DA perturbations and subsequent behavioural deficits, and responds to treatment with clozapine or NAC, with an additive effect following combination treatment.
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Cortical/hippocampal monoamines, HPA-axis changes and aversive behavior following stress and restress in an animal model of post-traumatic stress disorder
TL;DR: AS and RS differently effect the HPA-axis, evoking regional-specific brain monoamine changes that underlie maladaptive behavior and other post stress-related sequelae.