B
Brian J. Geiss
Researcher at Colorado State University
Publications - 71
Citations - 3373
Brian J. Geiss is an academic researcher from Colorado State University. The author has contributed to research in topics: RNA & Virus. The author has an hindex of 29, co-authored 65 publications receiving 2643 citations. Previous affiliations of Brian J. Geiss include Washington University in St. Louis & Saint Louis University.
Papers
More filters
Journal ArticleDOI
Paper-Based Microfluidic Devices: Emerging Themes and Applications
TL;DR: This work focuses on three-Dimensional Electrochemical Detection, which automates the very labor-intensive and therefore time-heavy and expensive process of characterize and characterize the electrochemical activity of the response of the immune system.
Journal ArticleDOI
Castanospermine, a Potent Inhibitor of Dengue Virus Infection In Vitro and In Vivo
Kevin Whitby,Theodore C. Pierson,Brian J. Geiss,Kelly Lane,Michael Engle,Yi Zhou,Robert W. Doms,Michael S. Diamond +7 more
TL;DR: It is suggested that castanospermine has a strong antiviral effect on dengue virus infection and warrants further development as a possible treatment in humans.
Journal ArticleDOI
The FDA-approved drug sofosbuvir inhibits Zika virus infection
Kristen M. Bullard-Feibelman,Jennifer Govero,Zhe Zhu,Vanessa Salazar,Milena Veselinovic,Michael S. Diamond,Brian J. Geiss +6 more
TL;DR: It is suggested that sofosbuvir may be a candidate for further evaluation as a therapy against ZIKV infection in humans, and should be evaluated as an anti‐ZIKV treatment in non‐rodent species.
Journal ArticleDOI
The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure
Moheshwarnath Issur,Brian J. Geiss,Isabelle Bougie,Frédéric Picard-Jean,Simon Despins,Joannie Mayette,Sarah E. Hobdey,Martin Bisaillon +7 more
TL;DR: This study provides biochemical evidence that flaviviruses encode a complete RNA capping machinery and demonstrates that GTP can be used as a substrate by the enzyme to form a covalent GMP-enzyme intermediate via a phosphoamide bond.
Journal ArticleDOI
A rapid and quantitative assay for measuring antibody-mediated neutralization of West Nile virus infection.
Theodore C. Pierson,Melissa D. Sánchez,Bridget A. Puffer,Asim A. Ahmed,Brian J. Geiss,Laura E. Valentine,Louis A. Altamura,Michael S. Diamond,Robert W. Doms +8 more
TL;DR: A novel approach for measuring antibody-mediated neutralization of WNV infection using virus-like particles that measure infection as a function of reporter gene expression is described.