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Brian L. Dake
Researcher at University of Iowa
Publications - 34
Citations - 1307
Brian L. Dake is an academic researcher from University of Iowa. The author has contributed to research in topics: Binding protein & Growth factor. The author has an hindex of 19, co-authored 34 publications receiving 1277 citations. Previous affiliations of Brian L. Dake include Royal Melbourne Hospital & Oregon Health & Science University.
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Journal ArticleDOI
Insulin differentially alters transcapillary movement of intravascular IGFBP-1, IGFBP-2 and endothelial cell IGF-binding proteins in the rat heart.
Robert S. Bar,Mary Boes,David R. Clemmons,Walker H. Busby,Alexander Sandra,Brian L. Dake,Barbara A. Booth +6 more
TL;DR: It is concluded that in the perfused rat heart, insulin can differentially alter transcapillary movement of IGFBP-1, IGF BP-2 and endothelial cell IGF-binding proteins, which could potentially mediate nutrient-dependent transport of IGF-I and IGF-II to peripheral tissues.
Journal ArticleDOI
Transcapillary Permeability and Subendothelial Distribution of Endothelial and Amniotic Fluid Insulin- Like Growth Factor Binding Proteins in the Rat Heart*
Robert S. Bar,David R. Clemmons,Mary Boes,Walker H. Busby,Barbara A. Booth,Brian L. Dake,Alexander Sandra +6 more
TL;DR: It is concluded that IGFBPs produced by endothelial cells and the IGFBP-1 contained in amniotic fluid can cross the capillary boundaries of the rat heart, and that the ECBPs preferentially localize in connective tissue elements of the myocardium, whereas IGF BP-1 predominantly localizes in cardiac muscle.
Journal ArticleDOI
Insulin, insulin-like growth factors, and vascular endothelium.
TL;DR: This report will focus on the interactions of insulin and the insulin-like growth factors (IGFs) with vascular endothelium, based on studies with cultured endothelial cells, isolated microvessels, and perfused organ systems.
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Endothelial cells express insulin-like growth factor-binding proteins 2 to 6.
David R. Moser,William L. Lowe,Brian L. Dake,Barbara A. Booth,Mary Boes,David R. Clemmons,Robert S. Bar +6 more
TL;DR: Cultured bovine endothelial cells synthesize and secrete IGFBP2, IGFBP3, and IGFBP4 and have mRNA specific for IGFBP 2, -3, -4, -5 and -6, which raises the interesting possibility that the vascular endothelium contributes to circulating and tissue levels of specific IGFBPs in vivo.
Journal ArticleDOI
Tissue Localization of Perfused Endothelial Cell IGF Binding Protein is Markedly Altered by Association with IGF-I
Robert S. Bar,Mary Boes,Brian L. Dake,Alexander Sandra,Marvin L. Bayne,Margaret A. Cascieri,Barbara A. Booth +6 more
TL;DR: It is concluded that ECBP in the presence of IGF will cross capillary boundaries and the tissue distribution of [ECBP-IGF-I] is dictated by the IGF-I molecule.