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Brian L Kotzin
Researcher at Amgen
Publications - 4
Citations - 709
Brian L Kotzin is an academic researcher from Amgen. The author has contributed to research in topics: Lupus erythematosus & Systemic lupus erythematosus. The author has an hindex of 4, co-authored 4 publications receiving 593 citations.
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Journal ArticleDOI
Phase 3 Studies Comparing Brodalumab with Ustekinumab in Psoriasis
Mark Lebwohl,Bruce Strober,Alan Menter,Kenneth B. Gordon,Jolanta Weglowska,Lluís Puig,Kim A. Papp,Lynda Spelman,Darryl Toth,Francisco A. Kerdel,April W. Armstrong,Georg Stingl,Alexa B. Kimball,Hervé Bachelez,Jashin J. Wu,Jeffrey J. Crowley,Richard G. Langley,Tomasz Blicharski,Carle Paul,Jean-Philippe Lacour,Stephen K. Tyring,Leon H Kircik,Sergio Chimenti,Kristina Callis Duffin,Jerry Bagel,John Koo,Gary Aras,Joanne Li,Wenjie Song,Cassandra E Milmont,Yifei Shi,Ngozi Erondu,Paul Klekotka,Brian L Kotzin,Ajay Nirula +34 more
TL;DR: Bdalumab treatment resulted in significant clinical improvements in patients with moderate-to-severe psoriasis, and was found to be superior to placebo at week 12 with respect to a 100% reduction in PASI score (PASI 100).
Journal ArticleDOI
New insights into disease pathogenesis from mouse lupus genetics.
TL;DR: The functional dissection of susceptibility loci in multigenic mouse models of lupus has provided insight into the immune abnormalities associated with autoantibody production and other processes critical for inflammation and damage in the kidney.
Journal ArticleDOI
Safety, pharmacokinetics and pharmacodynamics of AMG 811, an anti-interferon-γ monoclonal antibody, in SLE subjects without or with lupus nephritis.
Michael Boedigheimer,David Martin,Zahir Amoura,Jorge Sánchez-Guerrero,Juanita Romero-Diaz,Alan Kivitz,Cynthia Aranow,Tak Mao Chan,Yip Boon Chong,Kit Chiu,Christine Wang,Winnie Sohn,Gregory E. Arnold,Michael A. Damore,Andrew A. Welcher,Barbara A. Sullivan,Brian L Kotzin,James B. Chung +17 more
TL;DR: AMG 811 demonstrated favourable pharmacokinetics and acceptable safety profile but no evidence of clinical impact on SELENA-SLEDAI scores, proteinuria, C3 or C4 complement levels, or anti-dsDNA antibodies was observed.
Journal ArticleDOI
THU0389 A Multiple Dose Study of AMG 811 (Anti-IFN-Gamma) in Subjects with Systemic Lupus Erythematosus and Active Nephritis
David Martin,Zahir Amoura,Juanita Romero-Diaz,Yip Boon Chong,J. Sanchez-Guerrero,Tak Mao Chan,Gregory E. Arnold,Michael A. Damore,Winnie Sohn,Narendra Chirmule,Kit Chiu,Christine Wang,Michael Boedigheimer,Barbara A. Sullivan,Andrew A. Welcher,Brian L Kotzin,James B. Chung +16 more
TL;DR: AMG 811 demonstrated a favorable PK and immunogenicity profile in active LN subjects, and the overall safety profile was acceptable in this small study.