J
Jean-Philippe Lacour
Researcher at University of Nice Sophia Antipolis
Publications - 395
Citations - 12679
Jean-Philippe Lacour is an academic researcher from University of Nice Sophia Antipolis. The author has contributed to research in topics: Psoriasis & Internal medicine. The author has an hindex of 52, co-authored 379 publications receiving 10175 citations. Previous affiliations of Jean-Philippe Lacour include Centre Hospitalier Universitaire de Nice & Tufts University.
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Journal ArticleDOI
Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis
Eric L. Simpson,Thomas Bieber,Emma Guttman-Yassky,Lisa A. Beck,Andrew Blauvelt,Michael J. Cork,Jonathan I. Silverberg,Mette Deleuran,Yoko Kataoka,Jean-Philippe Lacour,Külli Kingo,Margitta Worm,Margitta Worm,Yves Poulin,Andreas Wollenberg,Yuhwen Soo,Neil M.H. Graham,Gianluca Pirozzi,Bolanle Akinlade,Heribert Staudinger,Vera Mastey,Laurent Eckert,Abhijit Gadkari,Neil Stahl,George D. Yancopoulos,Marius Ardeleanu +25 more
TL;DR: Dupilumab improved the signs and symptoms of atopic dermatitis, including pruritus, symptoms of anxiety and depression, and quality of life, as compared with placebo in two phase 3 trials of identical design.
Journal ArticleDOI
Phase 3 Studies Comparing Brodalumab with Ustekinumab in Psoriasis
Mark Lebwohl,Bruce Strober,Alan Menter,Kenneth B. Gordon,Jolanta Weglowska,Lluís Puig,Kim A. Papp,Lynda Spelman,Darryl Toth,Francisco A. Kerdel,April W. Armstrong,Georg Stingl,Alexa B. Kimball,Hervé Bachelez,Jashin J. Wu,Jeffrey J. Crowley,Richard G. Langley,Tomasz Blicharski,Carle Paul,Jean-Philippe Lacour,Stephen K. Tyring,Leon H Kircik,Sergio Chimenti,Kristina Callis Duffin,Jerry Bagel,John Koo,Gary Aras,Joanne Li,Wenjie Song,Cassandra E Milmont,Yifei Shi,Ngozi Erondu,Paul Klekotka,Brian L Kotzin,Ajay Nirula +34 more
TL;DR: Bdalumab treatment resulted in significant clinical improvements in patients with moderate-to-severe psoriasis, and was found to be superior to placebo at week 12 with respect to a 100% reduction in PASI score (PASI 100).
Journal ArticleDOI
Efficacy, safety and usability of secukinumab administration by autoinjector/pen in psoriasis: a randomized, controlled trial (JUNCTURE)
Carle Paul,Jean-Philippe Lacour,Tedremets L,K. Kreutzer,S. Jazayeri,S. Adams,Carrie Guindon,R. You,Charis Papavassilis +8 more
TL;DR: Secukinumab is a fully human anti–interleukin‐17A monoclonal antibody that has shown promise in combination with chemotherapy to treat central giant cell granuloma in animals.
Journal ArticleDOI
Baricitinib in patients with moderate-to-severe atopic dermatitis and inadequate response to topical corticosteroids: results from two randomized monotherapy phase III trials
Eric L. Simpson,Jean-Philippe Lacour,Lynda Spelman,R. Galimberti,Lawrence F. Eichenfield,Robert Bissonnette,Brett A. King,Jacob P. Thyssen,Jonathan I. Silverberg,T. Bieber,Kenji Kabashima,Y. Tsunemi,Antonio Costanzo,Emma Guttman-Yassky,Lisa A. Beck,Jonathan Janes,Amy M. DeLozier,Margaret Gamalo,Dennis Brinker,Tracy Cardillo,Fabio P. Nunes,Amy S. Paller,A. Wollenberg,Kristian Reich +23 more
TL;DR: Baricitinib, an oral selective Janus kinase 1 and 2 inhibitor, effectively reduced atopic dermatitis (AD) severity in a phase II study with concomitant topical corticosteroids.
Journal ArticleDOI
Defective Expression of Plectin/HD1 in Epidermolysis Bullosa Simplex with Muscular Dystrophy
Yannick Gache,Stéphane Chavanas,Jean-Philippe Lacour,Gerhard Wiche,Katsushi Owaribe,Guerrino Meneguzzi,Jean Paul Ortonne +6 more
TL;DR: The results provide strong evidence that, in MD-EBS patients, the defective expression of plectin results in an aberrant anchorage of cytoskeletal structures in keratinocytes and muscular fibers leading to cell fragility.