Brian Pulliam

TL;DR: Analysis of the complete asexual intraerythrocytic developmental cycle (IDC) transcriptome of the HB3 strain of P. falciparum demonstrates that this parasite has evolved an extremely specialized mode of transcriptional regulation that produces a continuous cascade of gene expression, beginning with genes corresponding to general cellular processes, such as protein synthesis, and ending with Plasmodium-specific functionalities.

TL;DR: Novel methods formulating nanoparticles into the form of micron-scale dry powders have been developed, which exhibit improved handling and delivery, while releasing nanoparticles upon deposition in the lungs.

TL;DR: The results suggest that melanoma pathogenesis can be understood as a series of distinct molecular events, and the gene expression signatures identified here provide the basis for developing new diagnostics and targeting therapies for patients with malignant melanoma.

TL;DR: DNA microarrays based on long oligonucleotides are powerful tools for the functional annotation and exploration of the P. falciparum genome and may serve as the basis for future drug targets and vaccine development.

TL;DR: The disadvantages observed with the existing hepatitis B vaccine administered by the parenteral route may be overcome by administering them as novel dry powders to the lungs, which have the advantage of eliciting a high mucosal immune response in the lungs without traditional adjuvants.