B
Brian R. Bond
Researcher at Medical University of South Carolina
Publications - 12
Citations - 1141
Brian R. Bond is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Endothelin receptor & Matrix metalloproteinase. The author has an hindex of 11, co-authored 12 publications receiving 1112 citations.
Papers
More filters
Journal ArticleDOI
A Matrix Metalloproteinase Induction/Activation System Exists in the Human Left Ventricular Myocardium and Is Upregulated in Heart Failure
Francis G. Spinale,Mytsi L. Coker,Lena J. Heung,Brian R. Bond,Himali R. Gunasinghe,Takuma Etoh,Aron T. Goldberg,James L. Zellner,A. Jackson Crumbley +8 more
TL;DR: Increased LV myocardial MMP activity and selective upregulation of MMPs with nonischemic and ischemic forms of DCM occurred and a local MMP induction/activation system was identified in isolated normal human LV myocytes that was upregulated with DCM.
Journal ArticleDOI
Myocardial matrix degradation and metalloproteinase activation in the failing heart: a potential therapeutic target
TL;DR: Increased LV myocardial MMP expression and activity are contributory factors in the LV remodeling process in cardiomyopathic disease states and Regulation of myocardian MMPexpression and activity may be an important therapeutic target for controlling myocardia matrix remodeling in the setting of developing heart failure.
Journal ArticleDOI
Matrix metalloproteinase expression and activity in isolated myocytes after neurohormonal stimulation
Mytsi L. Coker,Jennifer R. Jolly,Cassandra Joffs,Takuma Etoh,Jennifer R. Holder,Brian R. Bond,Francis G. Spinale +6 more
TL;DR: In this article, changes in myocardial matrix metalloproteinase (MMP) activity and expression have been associated with left ventricular (LV) remodeling, and a recent study demonstrated that LV myocytes synthesize and...
Journal ArticleDOI
Magnesium supplementation in the prevention of arrhythmias in pediatric patients undergoing surgery for congenital heart defects.
B.Hugh Dorman,Robert M. Sade,Jeffrey S. Burnette,Henry B. Wiles,Mark L. Pinosky,Scott Reeves,Brian R. Bond,Francis G. Spinale +7 more
TL;DR: Low magnesium levels in pediatric patients undergoing heart surgery are associated with an increased incidence of junctional ectopic tachycardia in the immediate postoperative period.
Journal ArticleDOI
Endothelin-1 during and after cardiopulmonary bypass: association to graft sensitivity and postoperative recovery.
Brian R. Bond,B.Hugh Dorman,Mark J. Clair,C.Allyson Walker,Mark L. Pinosky,Scott Reeves,Scott Walton,John M. Kratz,James L. Zellner,A. Jackson Crumbley,Marlina M. Multani,Francis G. Spinale +11 more
TL;DR: Systemic and pulmonary arterial endothelin levels remained increased for at least 24 hours postoperatively and prolonged pharmacologic management and increased intensive care unit stay were associated with increased systemicendothelin release and heightened graft-conduit sensitivity to endothelins.