M
Mytsi L. Coker
Researcher at Medical University of South Carolina
Publications - 19
Citations - 3522
Mytsi L. Coker is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Heart failure & Matrix metalloproteinase. The author has an hindex of 16, co-authored 19 publications receiving 3447 citations. Previous affiliations of Mytsi L. Coker include Baylor College of Medicine.
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Journal ArticleDOI
A Matrix Metalloproteinase Induction/Activation System Exists in the Human Left Ventricular Myocardium and Is Upregulated in Heart Failure
Francis G. Spinale,Mytsi L. Coker,Lena J. Heung,Brian R. Bond,Himali R. Gunasinghe,Takuma Etoh,Aron T. Goldberg,James L. Zellner,A. Jackson Crumbley +8 more
TL;DR: Increased LV myocardial MMP activity and selective upregulation of MMPs with nonischemic and ischemic forms of DCM occurred and a local MMP induction/activation system was identified in isolated normal human LV myocytes that was upregulated with DCM.
Journal ArticleDOI
Increased matrix metalloproteinase activity and selective upregulation in LV myocardium from patients with end-stage dilated cardiomyopathy.
Chadwick V. Thomas,Mytsi L. Coker,James L. Zellner,John R. Handy,A. Jackson Crumbley,Francis G. Spinale +5 more
TL;DR: Increased LV myocardial MMP activity and evidence for independent regulatory mechanisms of MMP and TIMP expression with DCM suggest that selective inhibition of M MP species within the LVMyocardium may provide a novel therapeutic target in patients withDCM.
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Time-Dependent Changes in Matrix Metalloproteinase Activity and Expression During the Progression of Congestive Heart Failure: Relation to Ventricular and Myocyte Function
Francis G. Spinale,Mytsi L. Coker,Chadwick V. Thomas,Jennifer D. Walker,Rupak Mukherjee,Latha Hebbar +5 more
TL;DR: SVT causes time-dependent changes in LV geometry and function and the subsequent development of CHF, suggesting that an early contributory mechanism for the initiation of LV remodeling that occurred in this model of developing CHF is enhanced expression and potentially increased activity of LV myocardial MMPs.
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Left Ventricular Remodeling in Transgenic Mice With Cardiac Restricted Overexpression of Tumor Necrosis Factor
Natarajan Sivasubramanian,Mytsi L. Coker,Karla M. Kurrelmeyer,William R. MacLellan,Francesco J. DeMayo,Francis G. Spinale,Douglas L. Mann,Douglas L. Mann +7 more
TL;DR: It is suggested that progressive time-dependent changes in the balance between MMP activity and TIMP activity are responsible, at least in part, for the spectrum of TNF-inducedChanges in the myofibrillar collagen content that occur during LV structural remodeling in the MHCsTNF mice.
Journal ArticleDOI
Matrix Metalloproteinase Inhibition During the Development of Congestive Heart Failure Effects on Left Ventricular Dimensions and Function
Francis G. Spinale,Mytsi L. Coker,Stephen R. Krombach,Rupak Mukherjee,Hussein Hallak,Ward V. Houck,Mark J. Clair,Scott B. Kribbs,Linda L. Johnson,J. Thomas Peterson,Michael R. Zile +10 more
TL;DR: Concomitant MMPi with developing CHF limited LV dilation and reduced wall stress, and it is suggested that increased myocardial MMP activity contributes to LV myocardian remodeling in developingCHF.